- A convenient and practical method for conversion of primary alkyl chlorides to highly pure bromides (≥99%)
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Repeated treatment (second after the aqueous work-up) of primary alkyl chlorides with ten equivalents (each) of lithium bromide in 3-pentanone at 120 °C for a total of five hours gave the corresponding bromides in excellent yield (86-96%) and with high chemical purity (≥99%).
- Li,Singh,Labrie
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Read Online
- HCl·DMPU-assisted one-pot and metal-free conversion of aldehydes to nitriles
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We report an efficient HCl·DMPU assisted one-pot conversion of aldehydes into nitriles. The use of HCl·DMPU as both an acidic source as well as a non-nucleophilic base constitutes an environmentally mild alternative for the preparation of nitriles. Our protocol proceeds smoothly without the use of toxic reagents and metal catalysts. Diverse functionalized aromatic, aliphatic and allylic aldehydes incorporating various functional groups were successfully converted to nitriles in excellent to quantitative yields. This protocol is characterized by a broad substrate scope, mild reaction conditions, and high scalability. This journal is
- Hammond, Gerald B.,Mudshinge, Sagar R.,Potnis, Chinmay S.,Xu, Bo
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supporting information
p. 4161 - 4164
(2020/07/14)
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- SUBSTITUTED IMIDAZOLES FOR THE INHIBITION OF TGF-BETA AND METHODS OF TREATMENT
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This disclosure relates to low molecular weight substituted imidazoles that inhibit the TGF-b signaling pathway. More specifically, this disclosure relates to methods of using said imidazoles for the treatment of diseases related to the TGF-b signaling pathways including, but not limited to, atherosclerosis, Marfan syndrome, Loeys-Dietz syndrome, obesity, diabetes, multiple sclerosis, keratoconus, idiopathic pulmonary fibrosis, Alzheimer's Disease, chronic kidney disease, and scleroderma.
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Paragraph 0042
(2020/03/15)
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- Preparation method of Roxadustat
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The invention discloses a preparation method of Roxadustat. The chemical name of Roxadustat is 2-[[5-bromo-4-(4-cyclopropyl-1-naphthalene)-4H-1,2,4-triazole-3-yl] sulfo] acetic acid. The molecular formula is C17H14BrN3O2S. The preparation process is concise, raw materials are easily available and the preparation process is economical and environmentally friendly, industrialization is achieved favorably, the economical technical development of bulk pharmaceutical chemicals of Roxadustat can be promoted, the production cost is lowered, the yield is high, the environmental pollution is slight, and the method is suitable for large-scaled production.
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Paragraph 0011; 0012; 0013
(2018/04/28)
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- C-substituted, 1H-azoles for amphoteric, solvent-less proton conductivity
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Disclosed herein are the compounds shown below. Also disclosed are methods of making the compounds. R1=—O—; R2=any alkyl chain; R3=—CH3, —CN, —COOCH3, -tetrazole, -imidazole, or -triazole; R4=—H or —R5; R5=—H, -halogen, —C≡CH, or —C≡C—; n is a positive integer; and m is a positive integer.
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- C-SUBSTITUTED, 1H-AZOLES FOR AMPHOTERIC, SOLVENT-LESS PROTON CONDUCTIVITY
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Disclosed herein are the compounds shown below. Also disclosed are methods of making the compounds. R1=—O—; R2=any alkyl chain; R3=—CH3, —CN, —COOCH3, -tetrazole, -imidazole, or -triazole; R4=—H or —R5; R5=—H, -halogen, —C≡CH, or —C≡C—; n is a positive integer; and m is a positive integer.
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Page/Page column
(2014/02/16)
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