- Thermosensitive recording material
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A thermosensitive recording material having a high whiteness and capable of forming clear colored images with an excellent resistance to oil and plasticizers is provided with a thermosensitive colored image-forming layer formed on a substrate sheet and comprising a substantially colorless dye precursor, a binder and a color-developing agent comprising at least one aromatic compound having, per molecule thereof, at least two functional sulfonylamino(thio)carbonylamino groups of the formula (I): wherein X is an oxygen or sulfur atom.
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- Palladium-catalyzed carbonylation of (arylsulfonyliminoido)-benzenes to arylsulfonyl isocyanates
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In the presence of palladium complexes as catalysts, carbonylation of (arylsulfonyliminoiodo)benzenes to arylsulfonyl isocyanates can be accomplished with 50-80% yield.
- Besenyei,Simandi
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p. 2839 - 2842
(2007/10/02)
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- Novel agents effective against solid tumors: The diarylsulfonylureas. Synthesis, activities, and analysis of quantitative structure-activity relationships
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A series of diarylsulfonylureas with exceptionally broad-spectrum activity against syngeneic rodent solid tumors in vivo is described. Their discovery resulted from a program dedicated to in vivo screening for novel oncolytics in solid tumor models, rather than traditional ascites leukemia models. The structures, oral efficacy, side-effect profile, and mechanism of action of these sulfonylureas appear to be distinct from previously known classes of oncolytics. An extensive series of analogues was prepared to probe structure-activity relationships (SAR), with particular focus on the substituent patterns of each aryl domain. Quantitative analysis of these substituent SARs, using the method of cluster significance analysis, showed the lipophilicity of the substituents to be the dominant determinant of activity. One compound from the series, LY186641 (104, sulofenur), has progressed to Phase I clinical trials as an antitumor drug.
- Howbert,Grossman,Crowell,Rieder,Harper,Kramer,Tao,Aikins,Poore,Rinzel,Grindey,Shaw,Todd
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p. 2393 - 2407
(2007/10/02)
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