- Simplified synthesis of 1,1′[14C]-methylene-di (2-naphthol). A radiochemical and kinetic approach
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The synthesis of the 1,1′[14C]-methylene-di-(2-naphthol) 2, as the radiolabeled probe of a possible interaction between the β-amyloid fibrils and the di-naphthol mojety in the Alzheimer's disease, is reported. Very simple radiochemical procedure, starting from [ 14C]paraformaldehyde, produced 8.66 MBq of compound 2 at the specific radioactivity of 1.22 TBq/mol. A mechanistic and kinetic approach allowed the comprehension of the right experimental conditions. The stability of compound 2 in acetonitrile solution was investigated, denoting a significative decomposition process through the transient formation of the 1,2-naphthyne intermediate. Copyright
- Angelini, Giancarlo,Ursini, Ornella,Minetti, Patrizia,Celona, Diana,De Angelis, Francesco
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p. 543 - 556
(2007/10/03)
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- Microwave-accelerated crossed cannizzaro reaction using barium hydroxide under solvent-free conditions
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A solventless and expeditious method for the preparation of alcohols is described from aldehydes using barium hydroxide, Ba(OH)2.8H2O, and paraformaldehyde. A comparison of this microwave-accelerated Cannizzaro reaction to the one under conventional heating mode is also reported.
- Varma, Rajender S.,Naicker, Kannan P.,Liesen, Per J.
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p. 8437 - 8440
(2007/10/03)
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