- A novel photosensitizer based on a ruthenium(ii) phenanthroline bis(perylenediimide) dyad: synthesis, generation of singlet oxygen and in vitro photodynamic therapy
-
In this study, a novel photosensitizer having two perylenediimide units and a phenanthroline ruthenium(ii) coordination moiety (Ru-BP) has been developed for photodynamic therapy (PDT) of cancer cells. This new compound was prepared via reactions of two n
- Aksakal, Nuray Esra,Kazan, Hasan Hüseyin,E?ik, Esra Tanriverdi,Yuksel, Fatma
-
p. 17538 - 17545
(2018/10/31)
-
- Palladium-Catalyzed Intramolecular Cyclization of Nitroalkenes: Synthesis of Thienopyrroles
-
In the presence of carbon monoxide, the palladium/phenanthroline system catalyzes the intramolecular amination of thiophene rings following the reduction of a nitroalkene moiety directly attached to the S-heterocyclic ring. Optimization of the ligand and reaction conditions allowed the synthesis of a series of thienopyrroles aryl/alkyl-substituted at either the 2- or 3-position of the pyrrole ring. By using low pressures of carbon monoxide (5 bars), high yields of fused bicyclic compounds have been obtained (up to 98 % yield).
- El-Atawy, Mohamed A.,Ferretti, Francesco,Ragaini, Fabio
-
p. 1902 - 1910
(2017/04/21)
-
- Copper-catalyzed N-arylation of imidazoles and benzimidazoles
-
(Chemical Equation Presented) 4,7-Dimethoxy-1,10-phenanthroline (L1c) was found to be an efficient ligand for the copper-catalyzed N-arylation of imidazoles and benzimidazoles with both aryl iodides and bromides under mild conditions. Further optimization of the system has revealed that the addition of poly(ethylene glycol) accelerates this reaction. A variety of hindered and functionalized imidazoles, benzimidazoles, and aryl halides were transformed in good to excellent yields. Heteroaryl halides were also coupled in moderate to good yields. We also present the results obtained from a series of coupling reactions, which directly compare the use of L1c with other recently reported ligands.
- Altman, Ryan A.,Koval, Erica D.,Buchwald, Stephen L.
-
p. 6190 - 6199
(2008/02/10)
-
- 4,7-Dimethoxy-1,10-phenanthroline: An excellent ligand for the Cu-catalyzed N-arylation of imidazoles
-
4,7-Dimethoxy-1,10-phenanthroline (L) was found to be an efficient ligand for the copper-catalyzed N-arylation of imidazole with aryl iodides and bromides under mild conditions. A variety of hindered and functionalized imidazoles and aryl halides were transformed in good to excellent yields.
- Altman, Ryan A.,Buchwald, Stephen L.
-
p. 2779 - 2782
(2007/10/03)
-
- The synthesis of aromatic diazatricycles from phenylenediamine-bis(methylene Meldrum's acid) derivatives
-
The thermocyclisation of phenylenediamine-bis(methylene Meldrum's acid) derivatives has been investigated. Those of o-phenylenediamines give 1,10-phenanthroline derivatives, while those of m- and p-phenylenediamines lead to the preferential formation of angular diazatricycles. Thus, for example, the di-Meldrum's acid derivative of 2,5-dichloro-1,4-phenylenediamine gives, via ipso-substitution, the unexpected angular product 19.
- Graf, Gabriele Ina,Hastreiter, Daniel,Da Silva, Luiz Everson,Rebelo, Ricardo Andrade,Montalban, Antonio Garrido,McKillop, Alexander
-
p. 9095 - 9100
(2007/10/03)
-
- The Synthesis of Pyridoquinolines with Dialkylaminopropylamine Side Chains
-
Several new pyridoquinolines with dimethylaminopropyl side chains including 4,7-bis(3'-dimethylaminopropylamino)-1,10-phenanthroline (1), 4,10-bis(3'-dimethylaminopropylamino)-1,7-phenanthroline (2), 4,10-bis(3'-dimethylaminopropylamino)-6-methyl-1,7-phen
- Molock, Frank F.,Boykin, David W.
-
p. 681 - 686
(2007/10/02)
-