- Tetra-(p-tolyl)antimony(III)-Containing Heteropolytungstates, [{(p-tolyl)SbIII}4(A-α-XW9O34)2]n- (X = P, As, or Ge): Synthesis, Structure, and Study of Antibacterial and Antitumor Activity
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We have synthesized and structurally characterized three tetra-(p-tolyl)antimony(III)-containing heteropolytungstates, [{(p-tolyl)SbIII}4(A-α-XW9O34)2]n- [X = PV (1-P), AsV (1-As), or GeIV (1-Ge)], in aqueous solution using conventional, one-pot procedures. The polyanions 1-P, 1-As, and 1-Ge were fully characterized in the solid state and in solution and were shown to be soluble and stable in aqueous medium at pH 7. Biological studies demonstrated that all three polyanions possess significant antibacterial and antitumor activities. The minimum inhibitory concentrations of 1-P, 1-As, and 1-Ge were determined against four kinds of bacteria, including the two pathogenic bacteria strains, Vibrio parahaemolyticus and Vibrio vulnificus. The three novel polyanions also showed high cytotoxic potency in the human cell lines A549 (non-small cell lung cancer), CH1/PA-1 (ovarian teratocarcinoma), and SW480 (colon carcinoma).
- Adǎscǎli?ei, Florin,Cavalli, Roberta,Cseh, Klaudia,Dammann, Inga,Donalisio, Manuela,Jakupec, Michael A.,Keppler, Bernhard K.,Kortz, Ulrich,Lembo, David,Li, Ming-Xing,Lin, Zhengguo,Ma, Tian,Mitea, Raluca,Mougharbel, Ali S.,Silvestru, Cristian,Thorstenson, Candice,Ullrich, Matthias S.,Yang, Peng
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supporting information
(2020/02/27)
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- Oxygen bridged hexa(organo)di-antimony compounds: Hydrolysis by traces of moisture and crystal structures of [SbR3Br]2O, where R = p-or o-tolyl
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1H and 13C NMR spectroscopy of four compounds of the type [SbR3X]2O, where X = Br and R = Ph, p-tolyl and o-tolyl or X = Cl and R = Me, have been interpreted as showing that unless stringent precautions are take
- Gibbons, Martin N.,Blake, Alexander J.,Sowerby, D. Bryan
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p. 217 - 225
(2007/10/03)
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- Two-step synthesis of triarylmetals (As, Sb, Bi) starting from the metal oxides and 2,6-dimethoxybenzenethiol
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Reported here is a new synthetic method of triarylmetals MAr3 (M = As, Sb, Bi). It is composed of two-step reactions starting from the metal oxides: (1) A reaction of the metal oxide with 2,6-dimethoxybenzenethiol ΦSH [Φ = 2,6-(MeO)2C6H3] in the presence of acid to give the thiolatometals M(SΦ)3, and (2) A reaction of M(SΦ)3 with organolithium reagent LiAr to give MAr3 (Ar = Ph, 4-MeC6H4, 4-Me2NC6H4, Φ). Since ΦSH is odorless and crystalline, most of it can be recovered after the reactions without difficulty for repeated usages. The intermediates M(SΦ)3 are also crystalline and inert against hydrolysis.
- Wada, Masanori,Natsume, Satoko,Suzuki, Shinobu,Uo, Akira,Nakamura, Michiaki,Hayase, Shuichi,Erabi, Tatsuo
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p. 223 - 227
(2007/10/03)
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- Tri- and di-arylantimony( V) thiocyanates and mixed halide thiocyanates; crystal structure of triphenylantimony( V) di-isothiocyanate
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A series of triarylantimony(V) dithiocyanates has been prepared by oxidising the appropriate antimony(III) compound with thiocyanogen. IR and 14N NMR spectroscopy indicate the presence of terminally N-bonded thiocyanate groups and this has been confirmed by a crystal structure determination for the SbPh3(NCS)2. The asymmetric unit contains three independent trigonal bipyramidal molecules, which differ in the orientations of the axial N-bonded thiocyanates and the phenyl groups in the equatorial plane, and there may be weak C-H ... S interactions. Treatment of SbPh2X3, where X = Br or Cl, with KSCN gave K[SbPh2(NCS)4] and attempts to prepare SbPh2(NCS)3 and related diphenylantimony(V) mixed halide thiocyanates, SbPh2Xn(NCS)3 - n where X = Br or Cl and n = 0-2, by treating appropriate diphenylantimony(III) precursors with thiocyanogen or thiocyanogen bromide or chloride gave products which in many cases underwent reorganisation during recrystallisation. Samples of SbPh2(NCS)3, SbPh2Br(NCS)2, SbPh2Br2(NCS) and SbPh2Cl2(NCS), and SbPh3Br(NCS) have, however, been isolated as microcrystalline solids.
- Forster, Glynis E.,Begley, Michael J.,Sowerby, D. Bryan
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p. 263 - 274
(2007/10/03)
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- Syntheses, Structures, and Equilibria of o-, m-, p-Tolyl- and Phenylantimony Rings
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Exchange reactions of R3Sb (R = o-Tol, m-Tol, p-Tol) with SbCl3 in a 1:2 molar ratio give RSbCl2.Silylstibanes RSb(SiMe3)2 were obtained by reaction of RSbCl2 and Me3SiCl with Mg in THF.Slow access of air to solutions of RSb(SiMe3)2 afforded orange crystals of the composition (RSb)n.Crystal structures were determined by X-ray crystallography fro R = o-Tol and m-Tol as stacks of (RSb)6 rings in the chair conformation with equatorial substituents.In the crystals of (m-TolSb)6 there are short intermolecular Sb***Sb distances of 420 pm.Solutions of (RSb)n (R = Ph, o-Tol, m-Tol, p-Tol) in C6D6 were analyzed by 1H-NMR spectroscopy.They contain (RSb)5 and (RSb)4 in equilibria.Raman spectra of (PhSb)6 or (p-TolSb)n show signals for Sbn at = 151 or 153 cm-1. 13C-CP-MAS-NMR data of (p-TolSb)n are reported. - Key Words: Cyclopentastibanes/ Cyclohexastibanes/ Antimony compounds/ Phenylantimony rings
- Breunig, Hans Joachim,Ebert, Klaus Heinz,Guelec, Sabahittin,Probst, Joachim
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p. 599 - 604
(2007/10/02)
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- 121Sb Moessbauer and 1H and 13C NMR Spectroscopic Studies of a Series of Organoantimony(V) Compounds, R3SbX2
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The 121Sb Moessbauer spectroscopic and the 1H and 13C NMR nuclear magnetic resonance studies have been performed for a series of organoantimony(V) compounds: R3SbX2 (R=CH3, C6H5, p-CH3C6H4; X=F, Cl, Br, I).For the trimethylantimony dihalides, the isomer shifts and quadrupole coupling constants of the 121Sb Moessbauer spectra indicated that the withdrawal of the bonding electrons from the antimony atom along Sb-X increased, as the electronegativity of the halogen increased.The chemical shifts of the 1H and 13C NMR spectra showed that the electron population around the methyl group increased with increasing electronegativity of halogen.For phenyl and p-tolyl derivatives, both 121Sb Moessbauer and 13C NMR data showed a trend similar to the methyl compounds.The results suggest that the electron cloud around the antimony atom spreads, with an increase in the electronegativity of the halogen, not only toward the halogen atoms but also toward the plane perpendicular to the bonding direction with the halogen atoms.
- Yanaga, Makoto,Miura, Taichi,Endo, Kazutoyo,Nakahara, Hiromichi,Takeda, Masuo
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p. 3085 - 3090
(2007/10/02)
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- ANTIMONY-SULPHUR BONDED COMPOUNDS. IV. FURTHER STUDIES ON THE THERMAL DECOMPOSITION OF TETRA-ORGANOANTIMONY MERCAPTIDES
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The thermolytic decompositions of Ph4SbSAr in organic solvents are reported.Solvent-derived products from decompositions in CCl4 and cyclohexane confirm the free radical nature of the reactions.Thermal decompositions of Ph3(p-MeC6H4)SbSC6H4OMe-p, or Ph(p-
- Bedi, Bhupinder S.,Grant, Douglas W.,Tewnion, Lesley,Wardell, James L.
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p. 251 - 266
(2007/10/02)
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