- Synthesis of 1-(α-Aminobenzyl)-2-naphthol derivatives, their structure in crystal and in solution
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The series of tautomeric 1,3-diarylnaphthoxazines (the Betti base precursors) was obtained by the interaction of 2-naphthols and 1,3,5-trisaryl-2,4-diazapenta-1,4-dienes. Their structure has been established in solid state and solution.
- Metlushka,Sadkova,Shaimardanova,Tufatullin,Zheltukhin,Kataeva,Alfonsov
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- Synthesis, antimicrobial and cytotoxicity study of 1,3-disubstituted-1H- naphtho[1,2-e][1,3]oxazines
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A series of new 1,3-disubstituted-1H-naphtho[1,2-e][1,3]oxazines (3 and 7) was synthesized in good yields and the structure was determined with the help of NMR, 2D-NMR, HRMS studies and X-ray crystallography. These compounds were tested in vitro for their
- Verma, Vikas,Singh, Kuldeep,Kumar, Devinder,Klap?tke, Thomas M.,Stierstorfer, J?rg,Narasimhan, Balasubramanian,Qazi, Asif Khurshid,Hamid, Abid,Jaglan, Sundeep
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p. 195 - 202
(2013/01/15)
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- Efficient synthesis of naphtho[1,2-e][1,3]oxazine derivatives via a chemoselective reaction with the aid of low-valent titanium reagent
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A series of new naphtho[1,2-e][1,3]oxazine derivatives such as trans-1,3-diaryl-1H-naphtho[1,2-e][1,3]oxazine-2(3H)-carbonyl chloride, 1-aryl-2-benzyl-1,2- dihydronaphtho[1,2-e][1,3]oxazine-3-one, and trans-1,3-diaryl-1H-naphtho[1,2-e] [1,3]oxazine-2(3H)-
- Shi, Daqing,Rong, Shaofeng,Dou, Guolan,Wang, Manman
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scheme or table
p. 25 - 30
(2010/10/03)
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- 1-(a-Aminobenzyl)-2-naphthol: A new chiral auxiliary for the synthesis of enantiopure a-aminophosphonic acids
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A new diastereoselective synthesis of a-aminophosphonates has been developed, based on the reaction, in the presence of trifluoroacetic acid, of trialkyl phosphites with chiral imines derived from (R)- or (S)-l-(ot- aminobenzyl)-2-naphthol. The reaction p
- Metlushka, Kirill E.,Kashemirov, Boris A.,Zheltukhin, Viktor F.,Sadkova, Dilyara N.,Buechner, Bernd,Hess, Christian,Kataeva, Olga N.,McKenna, Charles E.,Alfonsov, Vladimir A.
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supporting information; experimental part
p. 6718 - 6722
(2010/02/28)
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- Simple and convenient methods for synthesis, resolution and application of aminonaphthols
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Racemic aminonaphthols are obtained in 70-95% yield by simple and straightforward condensation of benzaldehyde, 2naphlhol and 1° or 2° amines in ethanol solvent under refluxing conditions. The racemic aminonaphthols 1-(αaminobcnzyl)-2-naphthol and 1-(α-pyrrolidinylbenzyl)-2-naphthol have been resolved using L -(+)-tartaric acid. The racemic l-(a-/V- butylaminobenzyl)-2-naphthol and l-(a-piperidylbenzyl)-2-naphthol have been resolved using fl-(+)-BINOL and boric acid. The racemic (2-methoxynaphth-1-yl) benzylamine is resolved using dibenzoyl-L-(-)-tartaric acid. The readiliy accessible chiral aminonaphthols are useful for resolution of important moieties like racemic BINOL, ibuprofen and mandclic acid.
- Periasamy, Mariappan,Anwar, Shaik,Reddy, Meda Narsi
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experimental part
p. 1261 - 1273
(2010/02/28)
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