- Exploration of piperidinols as potential antitubercular agents
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Novel drugs to treat tuberculosis are required and the identification of potential targets is important. Piperidinols have been identified as potential antimycobacterial agents (MIC 5 μg/mL), which also inhibit mycobacterial arylamine N-acetyltransferas
- Abuhammad, Areej,Fullam, Elizabeth,Bhakta, Sanjib,Russell, Angela J.,Morris, Garrett M.,Finn, Paul W.,Sim, Edith
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p. 16274 - 16290
(2015/02/19)
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- Synthesis and evaluation of anticonvulsant activities of some bis Mannich bases and corresponding piperidinols
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Some acetophenone derived bis Mannich bases (B1-B5) and piperidinols (C1, C4), which are the structural isomers of B1 and B4, and also quaternary piperidine derivative C6 were synthesized and studied for anticonvulsant activity. Of the compounds, C6 was reported for the first time. Chemical structures of the compounds were confirmed by UV, IR, 1H-NMR, 13C-NMR, mass spectra and elemental analysis. Their anticonvulsant activities were determined by maximal electroshock (MES), subcutaneous metrazol (scMet) tests and rotarod test for neurological deficits. According to the activity studies, B2, B4, C1 and C4 derivatives were found to be protective against MES at 30 mg/kg and above. B1, B2, B3, B4, C4 and C6 derivatives were found to be protective against scMet, at different dose levels ranging from 30 to 300 mg/kg. Since no neurotoxicity was detected for the compounds B4 and C4, they seem to be candidate compounds for further synthesis and in vivo studies for their potential anticonvulsant activity.
- Gul, Halise Inci,Calis, Unsal,Vepsalainen, Jouko
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p. 863 - 869
(2007/10/03)
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- Novel synthesis of 3-benzoyl-4-hydroxy-1-methyl-4-phenylpiperidine
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Unusual formation of 3-benzoyl-4-hydroxy-1-methyl-4-phenylpiperidine (3) is reported in the reaction of 3-bromopropiophenone (1) and methylamine.A possible mechanism of the reaction is also reported.
- Sharma, V L,Bhandari, K,Chatterjee S K
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p. 876 - 877
(2007/10/02)
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- Synthesis and preliminary study of some ring-substituted arylpropanonoamines and their quaternary salts
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The synthesis and biological examination of 1-phenyl- and 1-(4-bromophenyl)-3-(N-2-hydroxyethyl-N-methylamino) propan-1-one methiodides and 1-(4-bromophenyl)-3-(N-2-hydroxyethyl-N-methylamino)propan-1-ol methiodide as model potential intravenous anestheti
- Stenlake,Patrick,Sneader
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p. 591 - 597
(2007/10/02)
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