cas 5411-22-3, BENZPHETAMINE HYDROCHLORIDE--DEA

Articles about 5411-22-3Total 7 be found

Benzphetamine hydrochloride preparation method
The invention relates to the field of chemical pharmacy, particularly to a benzphetamine hydrochloride preparation method. According to the invention, the method avoids the use of ephedrine, pseudoephedrine, deoxyephedrine and other management and control products, has characteristics of inexpensive and easily-available raw materials and synthesis cost reducing, can obtain the high-purity target compound at high yield, and is suitable for industrial large-scale production.
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(2020/01/25)

Preparation method of benzphetamine hydrochloride
The invention relates to the field of chemical pharmacy, and in particular relates to a preparation method of benzphetamine hydrochloride. According to the method, the use of controlled products suchas ephedrine, pseudoephedrine, deoxyephedrine and the like is avoided; the raw materials are cheap and easy to obtain, so that the synthesis cost is reduced; by using the preparation method disclosedby the invention, the high-purity target compound can be obtained at high yield, and industrial large-scale production is easy.
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Paragraph 0015; 0104-0111

(2020/01/25)

An efficient, scalable process for benzphetamine hydrochloride
Commercial manufacturing of benzphetamine hydrochloride along with its impurity profiling is disclosed. Deoxygenation of pseudoephedrine is reported with ～100% retention by shielding the amine group as its tert-butyl carbamate, which is very straightforward to eliminate at the end. Four unknown process-related impurities are isolated from the samples of final API and characterized on the basis of their NMR and mass spectral analysis. Structures of the isolated impurities are confirmed by independent syntheses and coinjecting with the isolated one.
Pramanik, Chinmoy,Bapat, Kiran,Chaudhari, Ashok,Kulkarni, Mukund G.,Kolla, Rangarao,Sompalli, Srinivasarao,Tripathy, Narendra K.,Gurjar, Mukund K.
p. 495 - 500
(2014/05/06)

PROCESS FOR PREPARATION OF BENZPHETAMINE AND ITS PHARMACEUTICALLY ACCEPTABLE SALTS
The present invention provides a simple method for preparation of benzphetamine and its acid addition salt comprising reaction of methamphetamine hydrochloride of formula (III) with benzyl chloride and treating the isolated benzphetamine of formula (II) with an acid dissolved in an organic solvent to provide benzphetamine acid addition salt, more specifically, benzphetamine hydrochloride of formula (I).
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Page/Page column 3

(2011/04/14)

HIGHLY PURE CRYSTALLINE BENZPHETAMINE HYDROCHLORIDE AND PROCESSES FOR PREPARING
A highly pure crystalline form of benzphetamine hydrochloride and methods for the purification and crystallization of benzphetamine hydrochloride in high yield are disclosed.
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Page/Page column 8-10

(2008/12/05)

PROCESS FOR PREPARING BENZYLATED AMINES
This present invention relates to a process for preparing benzylated amines by the reaction of an amine selected from methamphetamine and propylhexedrine with benzyl halide. Numerous improvements are obtained by employing the amine in molar excess with respect to benzyl halide, preferably in a molar ratio of 2 to 1. The excess amine is employed to selectively neutralize by-product acid as the amine salt. The amine salt is then separated from the reaction mixture and basified to reclaim starting amine for recycle to the process.
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Page/Page column 7-8

(2008/06/13)

PROCESS FOR THE PURIFICATION OF BENZPHETAMINE HYDROCHLORIDE
The present invention relates to the economical and separation of benzphetamine hydrochloride and methamphetamine by liquid extraction. An extraction process employing a suitable organic solvent and water at a pH in the range of from about 6 to about 8 provides excellent removal of the methamphetamine by dissolution in the water phase while the benzphetamine dissolves in the organic phase. Simple separation of the two phases results in separation of the two amines.
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Page/Page column 5-6

(2008/06/13)