- 2-(3-Amino-2-hydroxy-propoxy)-mono-and diazines
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Heterocyclic compounds of the formula STR1 wherein Het denotes optionally substituted pyridazinyl, pyrimidinyl, pyrazinyl or substituted pyridyl, R1 is hydrogen or methyl and R2 is lower alklyl, optionally substituted phenyl-lower alkyl, carboxy-lower alkyl or functionally modified carboxy-lower alkyl, their condensation products with aldehydes, ketones or carbonic acid and their N-oxides, which are valuable (cardioselective) β-receptor blocking agents, and/or (cardioselective) β-receptor-stimulants.
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- Synthesis of Aminomethyl Crown Ethers
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Various N-substituted or unsubstituted aminomethyl crown ethers, which possess a reactive amino group, were prepared in good yields by the reaction between 3-amino-1,2-propanediols or aminomethyl oligoethylene glycols and oligoethylene glycol ditosylates or dichlorides.The scope of the reaction was investigated and the complexing ability of these new crown ether derivatives with sodium and potassium ions in methanol was measured by potentiometric titration.
- Maeda, Hirokazu,Kikui, Takashi,Nakatsuji, Yohji,Okahara, Mitsuo
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p. 5167 - 5171
(2007/10/02)
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- 2-(3-AMINO-2-HYDROXY-PROPOXY)-PYRAZINES
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Heterocyclic compounds of the formula STR1 wherein Het denotes optionally substituted pyridazinyl, pyrimidinyl, pyrazinyl or substituted pyridyl, R 1 is hydrogen or methyl and R 2 is lower alkyl, optionally substituted phenyl-lower alkyl, carboxy-lower alkyl or functionally modified carboxy-lower alkyl, their condensation products with aldehydes, ketones or carbonic acid and their N-oxides, which are valuable (cardioselective) β-rezeptor blocking agents, and/or (cardioselective) β-rezeptor-stimulants.
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