- New Non-ionic Polyol Derivatives with Sucrose Mimetic Properties
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New tris(hydroxymethyl)amidomethane and other non-ionic polyols derived from Cannizzaro condensations are reported, which feature molecular masses and carbon atom to hydroxy group ratios similar to those of sucrose; these materials are (in vitro) non-fermentable and accurately reproduce the non-gustatory properties of sucrose, which renders them useful as sugar macronutrient substitutes in low-calorie formulated foods.
- DuBois, Grant E.,Zhi, Benxin,Roy, Glenn M.,Stevens, Shawn Y.,Yalpani, Manssur
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- Construction of Pentacyclic Limonoid Skeletons via Radical Cascade Reactions
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Limonoids 1 and 2 share a 6/6/6/5-membered ABCD-ring system and a six-membered oxacycle and differ in their C9-stereochemistries. A new radical-based strategy was devised to construct the pentacyclic skeletons of 1 and 2. An oxacycle-fused A-ring and enyne fragments were coupled to produce radical precursors 4a-4c with different C7-oxygen functionalities. The bridgehead tertiary bromide of 4a-4c participated in a radical cascade reaction with the three unsaturated bonds to cyclize the C9-diastereomeric BCD-rings.
- Mutoh, Hiroyuki,Nakamura, Shu,Hagiwara, Koichi,Inoue, Masayuki
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p. 6869 - 6878
(2021/05/29)
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- Synthetic method of nemadectin (by machine translation)
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In the process of preparing the intermediate 1, the yield of the intermediate 2 is greatly improved, and when the intermediate 2 and paraformaldehyde are reacted to prepare the nicotinoyl chloride hydrochloride, the hydrochloride is reacted with the intermediate 2 to form the intermediate 2. (by machine translation)
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- Process for the preparation of polyalcohols
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PCT No. PCT/EP96/04922 Sec. 371 Date Oct. 5, 1998 Sec. 102(e) Date Oct. 5, 1998 PCT Filed Nov. 11, 1996 PCT Pub. No. WO97/17313 PCT Pub. Date May 15, 1997A process for the preparation of polyalcohols comprises the stages: (a) Reaction of an alkanal or ketone with formaldehyde in aqueous solution in the presence of a tertiary amine, to form a formates containing polyalcohol product mixture, (b) removal of water, excess tertiary amine, excess formaldehyde (c) heating of remaining mixture from (b) with removal of further formaldehyde and tertiary amine with formation of the formates of the polyalcohol, (d) transfer of tertiary amine removed from stage (b) and/or from stage (c), to synthesis stage (a) and/or to the subsequent transesterification stage (e), (e) transesterification of the resulting formates of the polyalcohol from stage (c) with an alcohol of the formula ROH in the presence of a transesterification catalyst to give polyalcohols and formates of the formula where R is a hydrocarbon radical, preferably alkyl of 1-6, particularly preferably 1-2, carbon atoms, and (f) isolation of the polyalcohols.
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