- Dynamic dye emission ON/OFF systems by a furan moiety exchange protocol
-
Four triphenylamine-based dyes were synthesized by fluorescence turn on reactions. Optical behaviours, molecular arrangements, donor-to-acceptor charge transfer and dipole interactions of these functional dyes were investigated by UV–vis absorption and fluorescence spectroscopy, single-crystal X-ray diffraction and electrochemical cyclic voltammetry. The irreversible isomerization of itaconimide dye leads to an irreversible emission switch ON to OFF. Reversible Diels-Alder reaction of these dyes lead to a reversible emission switch OFF/ON. These luminescent dyes demonstrate dynamic dye molecular features by furan moiety exchanges to form energy-minimized and optimized dye molecular structures. In the dynamic molecular system, α-position furan-substituted dye was converted into more stable β-position furan-substituted dye according to 1H NMR spectroscopic monitoring.
- Gong, Junbo,Wang, Ying,Zhang, Qi,Zhang, Xin
-
-
Read Online
- Synthesis preparation method of fluorene-based compound with 4-position substituent
-
The invention discloses a synthesis preparation method of a fluorene-based compound with 4-position substituent groups. The method is simple in step and convenient to control, is suitable for small preparation of laboratories, and is also suitable for ind
- -
-
Paragraph 0031-0033
(2021/09/15)
-
- PROGNOSTIC BIOMARKERS FOR TTK INHIBITOR CHEMOTHERAPY
-
The present invention provides a method for identifying a tumor - in a human individual or in an animal - that is susceptible to treatment with a TTK inhibitor, said method comprising: a] providing a sample of a tumor; b] determining the presence of a mutated CTNNB1 gene in said tumor sample, wherein said mutation is located in exon 3 of CTNNB1 and whereby the presence of a mutated CTNNB1 gene indicates that the tumor is susceptible to treatment with a TTK inhibitor. In an alternative aspect, step b] of the above defined method is replaced by the step of determining the presence of a mutated CTNNB1 protein in said tumor sample, wherein said mutation is located in exon 3 of CTNNB1 and whereby the presence of a mutated CTNNB1 protein indicates that the tumor is susceptible to treatment with a TTK inhibitor. In a further alternative, step b] comprises determining an altered expression of a CTNNB1 regulated gene, whereby an altered expression of a CTNNB1 regulated gene indicates that the tumor is susceptible to treatment with a TTK inhibitor.
- -
-
Page/Page column 50
(2016/10/31)
-
- Glucopyranosyl derivative and application thereof in medicines
-
The invention relates to a glucopyranosyl derivative used as a sodium-dependent glucose transporter (SGLT) inhibitor, a medicinal composition containing the derivative, and an application of the derivative and the medicinal composition in medicines, and especially relates to the glucopyranosyl derivative represented by formula (I) or a pharmaceutically acceptable salt or all stereoisomers thereof, or the medicinal composition containing the derivative, and a use of the derivative and the medicinal composition in the preparation of medicines for treating diabetes and diabetes related diseases.
- -
-
Paragraph 0610; 0611; 0612; 0613; 0614; 0615
(2016/10/08)
-
- MONOMERS AND POLYMERS DERIVED FROM NATURAL PHENOLS
-
Monomers, polymers and copolymers are provided that incorporate at least one naturally occurring phenolic compound, such as a plant phenol, as well as methods for producing the monomers and polymers. Plant phenols possessing a reactive group in addition t
- -
-
Paragraph 0120-0121
(2016/02/15)
-
- (5,6-DIHYDRO)PYRIMIDO[4,5-E]INDOLIZINES
-
The invention relates to a compound of Formula (I) wherein, R1 and R2 independently are selected from the group consisting of optionally substituted (6-10C)aryl and (1-5C)heteroaryl groups. The compounds can be used in pharmaceutical compositions, in particular in the treatment of cancer.
- -
-
Page/Page column 86
(2015/11/17)
-
- Dynamic Covalent Assembly of Peptoid-Based Ladder Oligomers by Vernier Templating
-
Dynamic covalent chemistry, in conjunction with template-directed assembly, enables the fabrication of extended nanostructures that are both precise and tough. Here we demonstrate the dynamic covalent assembly of peptoid-based molecular ladders with up to 12 rungs via scandium(III)-catalyzed imine metathesis by employing the principle of Vernier templating, where small precursor units with mismatched numbers of complementary functional groups are coreacted to yield larger structures with sizes determined by the respective precursor functionalities. Owing to their monomer diversity and synthetic accessibility, sequence-specific oligopeptoids bearing dynamic covalent pendant groups were employed as precursors for molecular ladder fabrication. The generated structures were characterized using matrix-assisted laser desorption/ionization mass spectrometry and gel permeation chromatography, confirming successful molecular ladder fabrication.
- Wei, Tao,Jung, Jae Hwan,Scott, Timothy F.
-
supporting information
p. 16196 - 16202
(2016/01/15)
-
- Soluble and reusable poly(norbornene) supports with high loading capacities for peptide synthesis
-
Poly(norbornene) supports comprising solubilizing ethylene glycol units and multiple amino acid attachment sites have been developed for peptide synthesis. A variety of amino acids have been efficiently loaded (0.6-1.1 mmol/g) onto the support in high yields (83-98%). Several tripeptides have been synthesized in moderate-to-good overall yields (41-66%) using only 1.2 equiv of coupling reagents/amino acids, and the support could be efficiently recycled up to 3 times.
- Naganna, Nimmashetti,Madhavan, Nandita
-
supporting information
p. 5870 - 5873
(2013/12/04)
-
- 4′-(2-(2-Ethoxyethoxy)ethoxy)biphenyl-4-carboxylic acid-a polar smectogen for amphipathic liquid crystals
-
We describe a new calamitic smectogen and some of its esters with a three-block molecular architecture (polar oxyethylene chain, rigid biphenyl and non-polar aliphatic chain) which were characterised by a combination of optical, thermical, X-ray and computational techniques. The title compound is a valuable smectogenic building block for amphipathic functional organic materials.
- Montani, Rosana S.,Hegguilustoy, Claudia M.,Del Rosso, Pablo G.,Donnio, Bertrand,Guillon, Daniel,Garay, Raúl O.
-
scheme or table
p. 5231 - 5234
(2009/12/06)
-
- Synthesis of penta-p-phenylenes with oligo(ethylene glycol) side chains
-
We report an efficient synthesis of a series of penta-p-phenylene derivatives with four side chains of various lengths, including deca(ethylene glycol) groups. The key feature of the synthesis is that the side chains are efficiently introduced in the last step, facilitating optimization of the side chains for different applications. Raman spectroscopy study indicates a similarly high rigidity for all these compounds, even those with long oligo(ethylene glycol) side chains. The deca(ethylene glycol)-substituted penta-p-phenylene derivatives are versatile building blocks for construction of nanometric, tripod-shaped adsorbates for biological applications.
- López-Romero, J. Manuel,Rico, Rodrigo,Martínez-Mallorquín, Rocío,Hierrezuelo, Jesús,Guillén, Elena,Cai, Chengzhi,Otero, J. Carlos,López-Tocón, Isabel
-
p. 6075 - 6079
(2008/03/12)
-
- The effect of polyether terminal chains in the liquid crystalline behavior of ortho-palladated complexes
-
A series of benzylideneanilines bearing terminal polyether chains, HL (HL = R-C6H4-CHN-C6H4-R′: R = OC8H17, R′ = O(CH2CH2O) 2C2H5; R = O(CH2CH 2O)2C2H5, R′ = OC 8H17; R = R′ = O(CH2CH2O) 2C2H5; R = OC12H25, R′ = O(CH2CH2O)3C2H 5; R = O(CH2CH2O)3C 2H5, R′ = OC12H25; R = R′ = O(CH2CH2O)3C2H 5) have been prepared. Their dinuclear, [Pd(μ-X)L]2 (X = OAc, Cl, Br, SC8), [Pd2(μ-SCn)(μ-X)L2] (X = OAc, Cl; n = 8, 2) and mononuclear orthopalladated derivatives, Pd(acac)L, Pd(Ala)L, are reported and their mesogenic properties are compared with those of the analogous compounds with alkoxy chains. In general a great lowering in the melting points is produced for all the products. The free ligands and the alanine complexes are not liquid crystals. The chloro-bridged complexes bearing alkoxy and short polyether chains (O(CH2CH2O) 2C2H5) show the larger improvement of mesogenic properties. Longer polyether chains (O(CH2CH2O) 3C2H5) result usually in a destabilization of the mesophases. If only polyether chains are present, the destabilization is important regardless of the chain length. The ability of these molecules as ionic extractants and transporters was qualitatively evaluated for the more propitious cis-dinuclear complexes, which in fact showed some extracting ability, modest but improved compared to the free ligands.
- Baena,Buey,Espinet,García-Prieto
-
p. 998 - 1010
(2007/10/03)
-
- Inhibition of secretory phospholipase A2. 2-Synthesis and structure-activity relationship studies of 4,5-dihydro-3-(4-tetradecyloxybenzyl) -1,2,4-4H-oxadiazol-5-one (PMS1062) derivatives specific for group II enzyme
-
We have recently reported the discovery of a series of specific inhibitors of human group IIA phospholipase A2 (hGIIA PLA2) to display promising in vitro and in vivo properties. Here we describe the influence of different structural modifications on the specificity and potency against hGIIA PLA2 versus porcine group IB PLA2. The SAR results, as well as the log P and pKa values of oxadiazolone determined in this work, provide important information towards the comprehension of the mode of action of this kind of compounds.
- Dong, Chang-Zhi,Ahamada-Himidi, Azali,Plocki, Stephanie,Aoun, Darina,Touaibia, Mohamed,Meddad-Bel Habich, Nadia,Huet, Jack,Redeuilh, Catherine,Ombetta, Jean-Edouard,Godfroid, Jean-Jacques,Massicot, France,Heymans, Francoise
-
p. 1989 - 2007
(2007/10/03)
-
- INDAZOLES SUBSTITUTED WITH1,1-DIOXOISOTHIAZOLIDINE USEFUL AS INHIBITORS OF CELL PROLIFERATION
-
The present invention relates to an indazole derivative, pharmaceutically acceptable salt, solvated product and isomer thereof substituted with 1,1-dioxoisothiazolidine which are useful as inhibitors for Cyclin Dependent Kinase (CDK). The present inventio
- -
-
-
- Synthesis and Biological Activity of Furanyl Anti-Juvenile Hormonal Compounds
-
Twenty-one synthetic compounds, containing one or more furan rings, were demonstrated to possess anti-juvenile hormone (AJH) activity as evidenced by their induction of premature metamorphosis in the milkweed bug, Oncopeltus fasciatus (Dallas) by contact, topical application or fumigation. The ED 50 of the four most active analogs required to induce precocious metamorphosis from 3rd-instar nymphs by residue contact in a Petri dish compared favorably with that of precocene II (6,7-dimethoxy-2,2-dimethyl 2H-chromene) a naturally occurring phytochemical AJH. Precocious metamorphosis was fully reversible by co-treatment with juvenile hormone (JH III) or JH analogs, demonstrating that the observed AJH activity resulted from an induced deficiency of juvenile hormone.
- Bowers, William S.,Unnithan, Gopalan C.,Fukushima, Jun-ichi,Toda, Jun,Sugiyama, Takeyoshi
-
-
- Perhydrotriquinacenic hosts. 1. Synthesis, complexation and transport properties of tripodands of C3 symmetry
-
A general strategy for the synthesis of tripodands of C3 symmetry, which involves the reductive amination of tricyclo[5.2.1.04,10]decane-2,5,8-trione 1, is described. Preliminary studies show that these tripodands exhibit complexatio
- Almansa, Carmen,Moyano, Albert,Serratosa, Felix
-
p. 5867 - 5876
(2007/10/02)
-
- Synthese et activite biologique de prodrogues de l'acide oxolinique
-
Synthesis and biological activities of oxolinic acid pro-drugs.Antiseptic phenols, anti-inflammatory acids and polyethyleneglycol moieties have been attached by labile bonds to oxolinic acid giving pro-drugs with anti-bacterial activities.Some of them are more soluble in water, exhibit a more sustained action in the time and give higher plasma and tissue concentrations compared with the free drug.
- Loubinoux, B,Colin, JL,Thomas, V
-
p. 461 - 467
(2007/10/02)
-
- Synthesis and Enantiomer Recognition of Dipodands and Crown Ethers Containing the 2,3:6,7-Dibenzobicyclonona-2,6-diene Residue as the Chiral Subunit
-
Five new optically active crown ethers and six optically active dipodands are reported.The crown ethers were synthesized by using (+)-(1S,4R,5S,8R)-2,3:6,7-dibenzobicyclonona-2,6-diene-4,8-diol and (+)-(1S,4R,5S,8R)-4,8-bis(hydroxymethyl)-2,3:6,7-d
- Naemura, Koichiro,Fukunaga, Rinko,Komatsu, Masanori,Yamanaka, Masatoshi,Chikamatsu, Hiroaki
-
-