- METHOD OF CONVERTING ALCOHOL TO HALIDE
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The present invention relates to a method of converting an alcohol into a corresponding halide. This method comprises reacting the alcohol with an optionally substituted aromatic carboxylic acid halide in presence of an N-substituted formamide to replace a hydroxyl group of the alcohol by a halogen atom. The present invention also relates to a method of converting an alcohol into a corresponding substitution product. The second method comprises: (a) performing the method of the invention of converting an alcohol into the corresponding halide; and (b) reacting the corresponding halide with a nucleophile to convert the halide into the nucleophilic substitution product.
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Page/Page column 53; 132; 142; 143
(2017/01/02)
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- HYDROCHLORINATION OF ELECTRON-DEFICIENT ALKENES
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The present invention pertains to a method for the hydrochlorination of electron deficient alkenes, particularly alkenes having the functional groups COOH, CONH2, and CN. Specific alkenes discussed include acrylic acid, crotonic acid, methacrylic acid, acrylonitrile, acrylamide, and methacrylonitrile. The alkene is combined with a primary or secondary alcohol (e.g., isopropanol) and an acid chloride (e.g., acetyl chloride) under conditions suitable to chlorinate the alkene. Products formed by the invention include 3-chorosubstituted carbonyl compounds such as 3-chlorpropionic acid (3-CPA), 3-chloropropionamide (3-CPAD), and 3-chloropropionitrile among other products.
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Page/Page column 5
(2012/07/31)
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- Trimethylchlorosilane and water. Convenient reagents for the regioselective hydrochlorination of olefins
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The hydrochlorination of a series of simple and functionalized olefins in high yields was readily accomplished using a mixture of trimethylchlorosilane and water. Hydrochlorination by this procedure is chemoselective and regioselective.
- Boudjouk, Philip,Kim, Beon-Kyu,Han, Byung-Hee
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p. 3479 - 3484
(2007/10/03)
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- AN EFFICIENT ONE-POT SYNTHESIS OF NITRILES FROM ACID CHLORIDES
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Treatment of aliphatic, aromatic as well as heterocyclic acid chlorides with sulfonamide in sulfolane at 120 deg C for 3 hours produces the corresponding nitriles in high yields.
- Hulkenberg, A.,Troost, J.J.
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p. 1505 - 1508
(2007/10/02)
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