- Pyrido[1,2-a]pyrimidone analogs as PI3K inhibitors
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The present invention discloses a class of pyrido[1,2-a]pyrimidone analogs as PI3K inhibitors, and particularly relates to a compound represented by a formula (I) or a pharmaceutically acceptable salt thereof. The formula (I) is defined in the specification.
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Paragraph 0370; 0375; 0376; 0377
(2016/10/08)
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- PYRIMIDINE COMPOUNDS AS TUBERCULOSIS INHIBITORS
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The present invention relates to compounds II useful as inhibitors of treating tuberculosis. The invention also provides processes for preparing compounds of the invention.
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Page/Page column 183
(2011/02/24)
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- α-Amino-α-vinyl-γ-butyrolactone derivatives from α-{[(trimethylsilyl)-methyl]alkylidene}-γ-butyrolactones
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N-Protected α-amino-α-vinyl-γ-butyrolactones 1 are obtained by the aza-Michael-type addition of NsONHCO2Et to novel silylated α-ylidene-γ-butyrolactones 2, through ring opening of the intermediate aziridine and loss of the trimethylsilyl group.
- Capuzzi, Marinella,Gambacorta, Augusto,Gasperi, Tecla,Loreto, M. Antonietta,Tardella, P. Antonio
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p. 5076 - 5082
(2007/10/03)
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- Linker nucleoside, and production and use of the same
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The present invention relates to a linker nucleoside, its preparation and use for the covalent bonding of biomolecules to oligonucleotides, in particular p-RNA oligonucleotides.
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Page column 10-11
(2010/02/05)
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- Diastereoselective hydrogenations of α-alkyl α-(2,3,4,6-tetra-O-acetyl-β-D-glucopyranosyloxy)methylene carbonyl compounds. New route to stereopure α-alkyl α-oxymethyl carbonyl compounds
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Wittig condensation of the stabilised phosphoranes 9, 10 and 26 with 1-formyl-2,3,4,6-tetra-O-acetyl-β-D-glucopyranose 11 leads to the vinylogous carbonates 12, 13 and 22. The salts 27-30 and 44, prepared from the corresponding carbonyl compounds, ethyl f
- Larsen, David S.,Schofield, Anthony,Stoodley, Richard J.,Tiffin, Peter D.
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p. 2487 - 2495
(2007/10/03)
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- SYNTHESIS OF α-ALKOXYLIDENE LACTONES
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The α-formylation of γ-lactones and the high yield conversion into their respective α-alkoxylidene lactones are described
- Murray, Alistair W.,Murray, Neil D.
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p. 853 - 858
(2007/10/02)
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- CONFIGURATION OF SODIUM SALT AND PREPARATION OF SULPHONATES AND CARBOXYLATES OF (E)- AND (Z)-3-(HYDROXYMETHYLENE)DIHYDRO-2(3H)-FURANONE
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The sodium salt of 3-(hydroxymethylene)dihydro-2(3H)-furanone (I) can be obtained in solid state in the form of (Z)-isomer, (E)-isomer, or their mixture, whereas in solutions it only exists in the form of (E)-isomer.Reactions of these sodium salts with su
- Jonas, Jaroslav
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p. 1907 - 1913
(2007/10/02)
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- A New Synthesis of α-Methylene Lactones
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The α-formylation of γ- and δ-lactones and the high yield conversion into their respective α-methylene γ- and δ-lactones are described.
- Murray, Alistair W.,Reid, Robert G.
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p. 132 - 133
(2007/10/02)
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