- Design, synthesis and biological evaluation of Schiff’s base derivatives as multifunctional agents for the treatment of Alzheimer’s disease
-
A series of Schiff’s base derivatives was rationally designed, synthesized, and evaluated as multi-function agents for the treatment of Alzheimer’s disease (AD). The results revealed that compound 3b was a novel multifunctional agent. It acted as a highly selective monoamine oxidase-B inhibitor (IC50 = 8.4 nM), which was explained by the docking study. Compound 3b also was an antioxidant agent (2.3 eq) and could significantly inhibit self-induced Aβ1-42 aggregation (31.8%). Meanwhile, compound 3b was a selective metal chelator and could inhibit Cu2+-induced Aβ1-42 aggregation (62.3%). Furthermore, compound 3b presented good neuroprotective effects on H2O2-induced PC12 cell injury. More importantly, compound demonstrated good blood brain barrier permeability and druglike properties. Therefore, compound 3b, a promising multi-targeted active molecule, offers an attractive starting point for further study in the drug-discovery process against AD.[Figure not available: see fulltext.].
- Shi, Jian,Zhou, Yi,Wang, Keren,Ma, Qinge,Wei, Rongrui,Li, Qingfeng,Zhao, Yiyang,Qiao, Zhanpin,Liu, Shuang,Leng, Yumin,Liu, Wenmin,Sang, Zhipei
-
p. 624 - 634
(2020/11/30)
-
- Phototriggered cytotoxic properties of tricarbonyl manganese(I) complexes bearing α-diimine ligands towards HepG2
-
Reaction between bromo tricarbonyl manganese(I) and N,N′-bis(phenyl)-1,4-diaza-1,3-butadiene ligands, bearing different electron-donating and electron-withdrawing groups R?=?OCH3, Cl, and NO2 in the ortho- and para-positions on the p
- Mansour, Ahmed M.,Radacki, Krzysztof,Khaled, Rabaa M.,Soliman, Marwa H.,Abdel-Ghani, Nour T.
-
p. 135 - 147
(2021/03/06)
-
- Synthesis and biological evaluation of novel cYY analogues targeting Mycobacterium tuberculosis CYP121A1
-
The rise in multidrug resistant (MDR) cases of tuberculosis (TB) has led to the need for the development of TB drugs with different mechanisms of action. The genome sequence of Mycobacterium tuberculosis (Mtb) revealed twenty different genes coding for cy
- Kishk, Safaa M.,McLean, Kirsty J.,Sood, Sakshi,Helal, Mohamed A.,Gomaa, Mohamed S.,Salama, Ismail,Mostafa, Samia M.,de Carvalho, Luiz Pedro S.,Munro, Andrew W.,Simons, Claire
-
supporting information
p. 1546 - 1561
(2019/03/05)
-
- Design and application of diimine-based copper(i) complexes in photoredox catalysis
-
Structurally different bis(imino)copper(i) complexes were prepared in a highly modular manner and utilized as copper-based photocatalysts in the ATRA reactions of styrenes and alkyl halides. The new photocatalysts showed good catalytic activity and ensured efficient chemical transformations.
- F?ldesi, Tamás,Sipos, Gellért,Adamik, Réka,Nagy, Bálint,Tóth, Balázs L.,Bényei, Attila,Szekeres, Krisztina J.,Láng, Gyz G.,Demeter, Attila,Peelen, Timothy J.,Novák, Zoltán
-
supporting information
p. 8343 - 8347
(2019/09/30)
-
- Molybdenum-catalyzed diastereoselective anti-dihydroxylation of secondary allylic alcohols
-
In this protocol, we report a Mo-catalyzed anti-dihydroxylation of secondary allylic alcohols, providing a general method for the preparation of 1,2,3-triols bearing up to three continuous stereocenters with excellent diastereocontrol. The mechanistic studies reveal that this dihydroxylation reaction consists of two steps and up to excellent diastereomeric ratios of the final triol products can be achieved due to the high level of both diastereocontrol in the initial epoxidation and regiocontrol in the following hydrolysis in situ.
- Su, Shixia,Wang, Chuan
-
supporting information
p. 2436 - 2440
(2019/03/29)
-
- Facile access to polymer supported zinc–salen complex: highly efficient heterogeneous catalyst for synthesizing hydantoins, thiohydantoins and Schiff bases in aqueous medium
-
The synthesis of polymer supported zinc–salen complex (PS-Zn–salen) is described. The mononuclear zinc(II)–salen complex was characterized by Fourier-transform NMR spectroscopy, energy-dispersive X-ray spectroscopy, Fourier transform infrared spectrophotometry (FT-IR), thermogravimetric analysis, scanning electron microscopy, surface area and pore size distribution by Brunauer–Emmett–Teller. The synthesized PS-Zn–salen complex used as a recyclable heterogeneous catalyst for the efficient synthesis of hydantoins, thiohydantoins and Schiff bases in an aqueous medium. The isolated yields of hydantoins, thiohydantoins and Schiff bases achieved up to 89, 95 and 94%, respectively. In spite of conventional heterogeneous catalysts, current PS-Zn–salen complex shows thermal stability up to 280?°C. Moreover, the catalyst could be recovered easily by simple filtration and reused for next run with slightly declining its activity up to six successive runs. The FT-IR spectrum of recycle catalyst after 6th run confirmed that the catalyst was stable during the course of a reaction. The leaching of metal from the PS-Zn–salen is negligible, which was confirmed by AAS and hot filtration test.
- Balinge, Kamlesh Rudreshwar,Khiratkar, Avinash Ganesh,Muskawar, Prashant Narayan,Thenmozhi,Bhagat, Pundlik Rambhau
-
p. 2075 - 2097
(2017/12/26)
-
- Condensation Product of 4-Methoxybenzaldehyde and Ethylenediamine: “Off-On” Fluorescent Sensor for Cerium(III)
-
The condensation product (L) of 4-methoxybenzaldehyde and ethylenediamine has been synthesised and characterised. L showed a 21 times enhancement in fluorescence intensity on interaction with Ce3+ in CH3OH at λmax = 360?nm
- Das, Diganta Kumar,Bharali, Bidisha,Goyari, Swrangsi
-
p. 1357 - 1361
(2018/09/29)
-
- Design, synthesis and evaluation against Mycobacterium tuberculosis of azole piperazine derivatives as dicyclotyrosine (cYY) mimics
-
Three series of azole piperazine derivatives that mimic dicyclotyrosine (cYY), the natural substrate of the essential Mycobacterium tuberculosis cytochrome P450 CYP121A1, were prepared and evaluated for binding affinity and inhibitory activity (MIC) against M. tuberculosis. Series A replaces one phenol group of cYY with a C3-imidazole moiety, series B includes a keto group on the hydrocarbon chain preceding the series A imidazole, whilst series C explores replacing the keto group of the piperidone ring of cYY with a CH2-imidazole or CH2-triazole moiety to enhance binding interaction with the heme of CYP121A1. The series displayed moderate to weak type II binding affinity for CYP121A1, with the exception of series B 10a, which displayed mixed type I binding. Of the three series, series C imidazole derivatives showed the best, although modest, inhibitory activity against M. tuberculosis (17d MIC = 12.5 μg/mL, 17a 50 μg/mL). Crystal structures were determined for CYP121A1 bound to series A compounds 6a and 6b that show the imidazole groups positioned directly above the haem iron with binding between the haem iron and imidazole nitrogen of both compounds at a distance of 2.2 ?. A model generated from a 1.5 ? crystal structure of CYP121A1 in complex with compound 10a showed different binding modes in agreement with the heterogeneous binding observed. Although the crystal structures of 6a and 6b would indicate binding with CYP121A1, the binding assays themselves did not allow confirmation of CYP121A1 as the target.
- El-wahab, Hend A.A. Abd,Accietto, Mauro,Marino, Leonardo B.,McLean, Kirsty J.,Levy, Colin W.,Abdel-Rahman, Hamdy M.,El-Gendy, Mahmoud A.,Munro, Andrew W.,Aboraia, Ahmed S.,Simons, Claire
-
p. 161 - 176
(2017/11/29)
-
- Photoinduced Copper(I)-Catalyzed Cyanation of Aromatic Halides at Room Temperature
-
The first photoinduced copper(I)-catalyzed cyanation of aromatic halides at room temperature has been developed. The sp2 cyanation reaction exhibits outstanding tolerance to functional groups including primary amines and carboxylic acids, and chemoselectivity to SN2-reactive alkyl chlorides. Mechanistic investigations indicate that the reaction occurs via a single-electron transfer (SET) between the aryl halide and an excited copper(I) cyanide catalytic intermediate. (Figure presented.).
- Kim, Kicheol,Hong, Soon Hyeok
-
supporting information
p. 2345 - 2351
(2017/07/22)
-
- One-pot synthesis of imidazolinium salts via the ring opening of tetrahydrofuran
-
A new one-pot synthesis of C2-hydroxypropyl-substituted imidazolinium salts via the ring opening of tetrahydrofuran (THF) with N,N′-disubstituted diamines has been developed. Preliminary studies of the reaction mechanism suggest the CO2-promoted oxidative ring opening of THF followed by Hg(ii)-mediated oxidation of an imidazolidine intermediate. These novel C2-substituted imidazolinium salts have shown to be active catalysts for the aza-Diels-Alder reactions.
- Huang, Yong-Qing,Zhao, Yue,Wang, Peng,Okamura, Taka-Aki,Laforteza, Brian N.,Lu, Yi,Sun, Wei-Yin,Yu, Jin-Quan
-
supporting information
p. 12430 - 12433
(2017/10/06)
-
- Synthesis and in vitro antioxidant evaluation of new bis(α-aminoalkyl)phosphinic acid derivatives
-
Diamines were added to arylaldehydes in ethanol, which resulted in corresponding diimines. Novel bis-1-aminophosphinic acid compounds were synthesized through the interaction of diimines and hypophosphorous acid. The new compounds were characterized by elemental analyses, FT-IR and1H,13C and31P NMR techniques. The in vitro antioxidant activity of the newly synthesized compounds were measured and found to exhibit significantly higher antioxidant activity than the standard.
- Sarac, Kamiran,Orek, Cahit,Cetin, Ahmet,Dastan, Taner,Koparir, Pelin,Dastan, Sevgi Durna,Koparir, Metin
-
p. 1284 - 1289
(2016/08/31)
-
- A new family of doubly cyclopalladated diimines. A remarkable effect of the linker between the metalated units on their cytotoxicity
-
The cyclopalladation of a series of symmetric diimines with the formula (RC6H4CH=NZ)2, where Z = CH2 or (CH2)2OCH2 and R = p-Cl, p-OMe, p-NO 2, and o-Cl, is described. Optimal conditions to obtain the dimetalated compounds were found to be palladium(II) acetate, in toluene, at 60 °C and with a reaction time of 2-4 h. The reactivity of the dimetalated compounds with monodentate, bidentate, and bis(monodentate) Lewis bases was also studied. The cytotoxic activity of some selected compounds was evaluated against a panel of adenocarcinoma cell lines (colon HCT116 and breast MCF7 and MDA-MB231). Compounds containing the fragment NCH2CH 2OCH2CH2OCH2CH2N exhibited a remarkable cytotoxic activity in the three cancer cells assayed, but complexes containing the NCH2CH2N fragment showed no activity. It seems that the length and flexibility of the central saturated chain in the imine molecule, as well as its lipophilicity and hydrophilicity, explain the different cytotoxicity of the two series of coordination compounds here reported.
- Albert, Joan,Bosque, Ramon,Cadena, Magali,D'Andrea, Lucia,Granell, Jaume,Gonzalez, Asensio,Quirante, Josefina,Calvis, Carmen,Messeguer, Ramon,Badia, Josefa,Baldoma, Laura,Calvet, Teresa,Font-Bardia, Merce
-
supporting information
p. 2862 - 2873
(2014/06/24)
-
- Synthesis, ir and nmr spectral correlations in some symmetrical diimines
-
A series of diimines have been synthesized by coupling of diamine with substituted benzaldehydes. The purities of these diimines were checked by their analytical and spectroscopic data. The spectral frequencies vCN (cm-1), NMR chemical shifts (v, ppm) of C-H and C=N of these diimines have been correlated with Hammett substituent constants, F and R parameters using single and multi-linear regression analysis. From the results of statistical analysis, the effect of substituents on the above spectral data has been studied.
- Thirunarayanan
-
-
- Synthesis and tripanocidal activity of ferrocenyl and benzyl diamines against Trypanosoma brucei and Trypanosoma cruzi
-
Trypanosoma brucei and Trypanosoma cruzi are the etiologic agents of sleeping sickness and Chagas disease, respectively, two of the 17 preventable tropical infectious diseases (NTD) which have been neglected by governments and organizations working in the health sector, as well as pharmaceutical industries. High toxicity and resistance are problems of the conventional drugs employed against trypanosomiasis, hence the need for the development of new drugs with trypanocidal activity. In this work we have evaluated the trypanocidal activity of a series of N1,N2-dibenzylethane-1,2-diamine hydrochlorides (benzyl diamines) and N1-benzyl,N2-methyferrocenylethane-1,2- diamine hydrochlorides (ferrocenyl diamines) against T. brucei and T. cruzi parasite strains. We show that incorporation of the ferrocenyl group into the benzyl diamines increases the trypanocidal activity. The molecules exhibit potential trypanocidal activity in vitro against all parasite strains. Cytotoxicity assay was also carried out to evaluate the toxicity in HepG2 cells.
- Velásquez, Angela Maria Arenas,Francisco, Acácio Ivo,Kohatsu, Andréa Akiko Nakaima,Silva, Flavia Alves De Jesus,Rodrigues, Danilo Fernando,Teixeira, Rafaela Gomes Da Silva,Chiari, Bruna Galdorfini,De Almeida, Maria Gabriela José,Isaac, Vera Lucia Borges,Vargas, Maria D.,Cicarelli, Regina Maria Barretto
-
p. 1707 - 1710
(2014/04/17)
-
- Silver(I) complexes with symmetrical Schiff bases: Synthesis, structural characterization, DFT studies and antimycobacterial assays
-
Synthesis, structural and spectroscopic characterizations, molecular modeling and antimycobacterial assays of new silver(I) complexes with two Schiff bases - MBDA and MBDB - are reported. The complexes [Ag(MBDA) 2]NO3, or AgMBDA, and
- Paiva, Isabela L.,De Carvalho, Gustavo S.G.,Da Silva, Adilson D.,Corbi, Pedro P.,Bergamini, Fernando R.G.,Formiga, André L.B.,Diniz, Renata,Do Carmo, Weberton R.,Leite, Clarice Q.F.,Pavan, Fernando R.,Cuin, Alexandre
-
p. 104 - 109
(2013/10/22)
-
- FBXO3 INHIBITORS
-
The present application discloses benzathine and related compounds and their use as FBXO-3 inhibitors.
- -
-
Page/Page column 51; 52
(2014/01/08)
-
- Synthesis, cytotoxicity, antibacterial and antileishmanial activities of imidazolidine and hexahydropyrimidine derivatives
-
This paper describes the synthesis and in vitro biological activities of imidazolidine and hexahydropyrimidine derivatives against bacteria (Escherichia coli, Staphylococcus aureus and Mycobacterium tuberculosis) and Leishmania protozoa. Out of sixteen heterocyclic derivatives tested, none were cytotoxic against mammalian cells. The compounds showed significant bacterial effects and leishmanicidal activity. Compounds 4a and 4c were active against S. aureus and E. coli, respectively. Compounds 3a-3f, 4h and 4i presented promising results against M. tuberculosis, with MIC values ranging from 12.5 to 25.0 μg/mL, comparable to the "first and second line" drugs used to treat tuberculosis. Compounds 4a, 4c and 4e were active against L major. Three of them were structurally characterized by single-crystal X-ray diffraction.
- De Carvalho, Gustavo S. G.,Dias, Rafael M. P.,Pavan, Fernando R.,Leite, Clarice Q. F.,Silva, Vania L.,Diniz, Cláudio G.,De Paula, Daniela T. S.,Coimbra, Elaine S.,Retailleau, Pascal,Da Silva, Adilson D.
-
p. 351 - 359
(2013/07/28)
-
- Zn2+-K10-clay (clayzic) as an efficient water-tolerant, solid acid catalyst for the synthesis of benzimidazoles and quinoxalines at room temperature
-
A very simple, green and efficient protocol is developed in which zinc chloride-exchanged K10-montmorillonite (clayzic) is employed as a Lewis acid catalyst in aqueous media at room temperature for the synthesis of various benzimidazoles and quinoxalines from carbonyl compounds and o-phenylenediamine. Among the various catalysts (including claycop and Zn2+-Y) studied, clayzic produces benzimidazoles and quinoxalines in higher yield, and with a flexible diamine such as ethylenediamine only the bis-Schiff base is formed. Other salient features of this protocol include milder conditions, atom-economy, absence of coupling agents, and no wastes.
- Dhakshinamoorthy, Amarajothi,Kanagaraj, Kuppusamy,Pitchumani, Kasi
-
supporting information; scheme or table
p. 69 - 73
(2011/02/25)
-
- Reversible aminal formation: Controlling the evaporation of bioactive volatiles by dynamic combinatorial/covalent chemistry
-
Dynamic mixtures generated by reversible aminal formation efficiently prolong the duration of evaporation of bioactive volatile aldehydes. Secondary diamines used for the generation of dynamic mixtures are obtained by treatment of primary diamines with carbonyl compounds and reduction of the diimines with NaBH4. The reversibilities of the reactions were demonstrated by NMR measurements in buffered aqueous solutions. Kinetic rate constants and equilibrium constants for the formation and hydrolysis of aminals were determined. The performance of dynamic mixtures as delivery systems for perfumery ingredients was tested after deposition onto cotton, and the long-lastingness of fragrance evaporation was investigated by dynamic headspace analysis against a reference sample. The simplicity of the concept together with its excellent performance makes this delivery system highly interesting for applied perfumery. Reversible aminal formation might also be successfully applicable to dynamic combinatorial/covalent chemistry for screening of pharmaceutically or catalytically active ligands and receptors. The evaporation of bioactive volatiles that are emitted from flowers to attract insects and that are used as fragrances in our everyday life is limited in time. Dynamic mixtures obtained by reversible aminal formation of suitably designed diamines with volatile aldehydes prolong the perception of these compounds in functional perfumery.
- Buchsnee Levrand, Barbara,Godin, Guillaume,Trachsel, Alain,De Saint Laumer, Jean-Yves,Lehn, Jean-Marie,Herrmann, Andreas
-
supporting information; experimental part
p. 681 - 695
(2011/03/22)
-
- Achiral bis-imine in combination with CoCI2: A remarkable effect on enantioselectivity of lipasemediated acetylation of racemic secondary alcohol
-
A bis-imine (prepared via a new FeCl3-based method) in combination with CoCl2 facilitated lipase-mediated acetylation of the (R)-isomer of a racemic benzylic secondary alcohol with 91% ees. The methodology was used for the preparation of the known drug rivastigmine.
- Arunkumar,Appi Reddy,Sravan Kumar,Vijaya Kumar,Chandrasekhar,Rajender Kumar,Pal, Manojit
-
supporting information; experimental part
p. 1174 - 1179
(2011/03/22)
-
- Synthesis, spectroscopic studies and crystal structures of ReI(CO)3(NN)Cl complexes with N,Nae-bis(substituted benzylidene)ethane-1,2-diamine Schiff base ligands
-
Four new Re(I) tricarbonyl-diimine complexes were prepared by reaction of Re(CO)5Cl with N,Nae-bis(substituted benzylidene)ethane-1,2-diamine Schiff base ligands. These compounds were characterized by physico-chemical methods, and their crystal
- Mirkhani, Valiollah,Kia, Reza,Milic, Dalibor,Vartooni, Akbar Rostami,Matkovic-Calogovic, Dubravka
-
experimental part
p. 81 - 87
(2011/12/14)
-
- Interaction of drug based binuclear mixed-ligand complexes with DNA
-
Here in we tried to increase an antibacterial activity of ciprofloxacin drug due to formation of mixed-ligand complexes. Synthesized compounds were found to be more potent compare to drugs, ligands and metal salt against selective gram(+ve) and
- Patel, Mohan N.,Chhasatia, Mehulsinh R.,Gandhi, Deepen S.
-
experimental part
p. 5648 - 5655
(2009/12/06)
-
- Synthesis of [N, N'-Bis(5-benzoyl-4-phenylthiazol-2-yl)-N, N-bisbenzyl]ethane-1, 2-diamines
-
Synthesis of [N,N'-bis(N-benzoylthiocarbamoyl)-N,N'-bis(benzyl)]ethane-1,2- diamines 4a-h, their cyclization to [N,N'-bis(5-benzoyl-4-phenylthiazol-2-yl)-N, N'-bisbenzyl]ethane-1,2-diamines 5a-h by reaction with phenacyl bromide and the results of antibacterial activity assay of 4a-h and 5a-h are reported.
- Asha,Manju,Pradeep,George,Rajasekharan
-
scheme or table
p. 1726 - 1730
(2009/05/30)
-
- Microwave-assisted efficient synthesis of diimines in dry media using silica gel supported sodium hydrogen sulfate as reusable solid support
-
A simple and efficient method for synthesis of diimines using silica gel supported sodium hydrogen sulfate as reusable solid support in solvent-free conditions under microwave irradiation is described.
- Bazgir, Ayoob
-
-
- A convenient "one-pot" reaction for selective monoalkylation of N,N′-disubstituted ethylenediamines
-
A study on the scope of the method to obtain N,N,N′-trisubstituted ethylenediamines III by monoalkylation of N,N′-disubstituted ethylenediamines I through a "one-pot" reaction is presented. It involves condensation of compounds I with aldehydes followed by reduction of the formed imidazolidines II without previous isolation.
- Salerno, Alejandra,Figueroa, Maria Amalia,Perillo, Isabel A.
-
p. 3193 - 3204
(2007/10/03)
-
- Synthesis, biological and catalytic properties of Ru(II) benzamides Schiff base complexes
-
A few Schiff bases (p-chlorobenzaldehyde)-benzylimine 1, (salicylaldehyde)-p-toluidiimine 2, bis(p-anisaldehyde)-ethylenediimine 3, bis(1-naphthaldehyde)-p-phenylenediimine 4, bis(m-nitrobenzaldehyde)-p-phenylenediimine 5, and bis(salicylaldehyde)-o-phenylenediimine 6 have been synthesized and reacted with Ru2Cl2(DNBH)(H2O)4 (TR1) to yield six binuclear ruthenium complexes 1a-6a. All the complexes are characterized by spectroscopic, elemental and magnetic susceptibility data. The coordination is found to be through carbonyl oxygen of amide, phenolic oxygen and azomethine nitrogen of the Schiff bases in the octahedral environment of the metal. All the metal complexes show antibacterial and catalytic activity.
- Jhaumeer-Laulloo,Bhowon, Minu G.
-
p. 2536 - 2540
(2007/10/03)
-
- A facile synthesis and characterization of the novel 2,2-dichloro-1-[3-(2,2-dichloro-acetyl)-2-(4-methoxy-phenyl)-imidazolidin -1-yl]-ethanone
-
The synthesis of (2,2-dichloro-1-[3-(2,2-dichloro-acetyl)-2-(4-methoxy-phenyl)-imidazolidin -1-yl]-ethanone by a facile one-pot reaction between N,N′-bis(4-methoxy-benzylidene)-ethane-1,2-diamine and dichloroacetyl chloride is described. The structure was
- Uenaleroglu, Canan,Temelli, Baris,Hoekelek, Tuncer
-
p. 3255 - 3261
(2007/10/03)
-
- Tetrahydroimidazoles - A promising group of expected NSAIDS - Their synthesis and anti-inflammatory activity
-
Several new 1, 2, 3-trisubstituted tetrahydroimidazoles (11-28) have been synthesised and their structures elucidated on the basis of spectral data. These compounds show promising anti-inflammatory activity by carrageenin induced paw edema test in rats and few of them showed an activity better than indomethacin.
- Khan,Chawla, Gita
-
p. 653 - 663
(2007/10/03)
-
- Modeling and biological evaluation of 3,3′-(1,2-ethanediyl)bis[2-(4-methoxyphenyl)-thiazolidin-4-one], a new synthetic cyclooxygenase-2 inhibitor
-
Within the series of chiral 3,3′-(1,2-ethanediyl)bis[2-arylthiazolidin-4-ones], the 3,4-dimethoxyphenyl substituted derivative was found in the primary anti-inflammatory screening to be endowed with superior in vivo properties and good safety profile. Suc
- Ottaná, Rosaria,Mazzon, Emanuela,Dugo, Laura,Monforte, Francesca,Maccari, Rosanna,Sautebin, Lidia,De Luca, Grazia,Vigorita, Maria Gabriella,Alcaro, Stefano,Ortuso, Francesco,Caputi, Achille P,Cuzzocrea, Salvatore
-
-
- Conformational and structural analysis of N-N′-bis (4-methoxybenzylidene)ethylenediamine
-
The Schiff base compound, N-N′-bis(4-methoxybenzylidene)ethylenediamine (C18H20N2O2) has been synthesized and its crystal structure has been investigated by X-ray analysis and PM3 method. The compound crystalliz
- ünalero?lu,Temelli,H?kelek
-
-
- Synthesis of imines, diimines and macrocyclic diimines as possible ligands, in aqueous solution
-
Although it is recognized that the presence of water is disadvantageous for imine synthesis, we demonstrate that such synthesis can be effective in completely aqueous media, without any catalyst and under mild conditions. Thus, arylaryl, aryl-alkyl, alkyl-aryl and alkyl-alkyl monoimines as well as a large variety of diimines are obtained by direct condensation of the corresponding carbonyl compounds and amines, in water. The same process is used to synthesize macrocyclic diimines starting from methylene, ethylene, trimethylene and tetramethylene glycol bis(2-formylphenyl ether) and ethylene-, trimethylene- and tetramethylene-diamine, some of these macrocycles being known for their chelating properties.
- Simion, Alina,Simion, Cristian,Kanda, Tadeshige,Nagashima, Satoko,Mitoma, Yoshiharu,Yamada, Tomoko,Mimura, Keisuke,Tashiro, Masashi
-
p. 2071 - 2078
(2007/10/03)
-
- Synthesis of novel tetrahydroimidazole derivatives and studies for their biological properties
-
Ethylenediamine was reacted with suitable aromatic aldehydes in order to prepare their respective diSchiff bases. These compounds were then reduced to give the corresponding tetrahydrodiSchiff bases, which were low melting in nature. Finally, these derivatives were condensed with different aromatic aldehydes to give the desired tetrahydroimidazoles. The structures of all these compounds were established on the basis of spectral data. These novel tetrahydroimidazoles showed promising anti-inflammatory and analgesic activity. The compounds were also screened for their anti-bacterial property against Staphylococcus aureus and Escherichia coli.
- Sharma, Vibha,Khan
-
p. 651 - 658
(2007/10/03)
-
- Stereoselective synthesis of cis-bis-β-lactams linked with an ethylene bridge
-
An efficient synthesis of (±)-cis-bis-β-lactams (5 and 6) via cycloaddition reaction of bisimines (3a-c) with acid chlorides (4) in the presence of triethylamine in very good yield is described. (C) 2000 Published by Elsevier Science Ltd.
- Karupaiyan,Puranik,Deshmukh,Bhawal
-
p. 8555 - 8560
(2007/10/03)
-
- Light-induced cooperative electron-proton transfer in hydrogen-bonded networks of N,N-diaryl substituted 1,4-bisimines and meso-1,2-diaryl-1,2-ethanediols
-
The 1:1 cocrystallization of 1,4-diaryl-1,4-bis-imines (Ar-CH=N-CH2-)2 4-11 and substituted meso-1,2-diaryl-1,2-ethanediols 1-3 leads to supramolecular structures in which the diol is hydrogen bonded by one of its hydroxy groups to a
- Felderhoff, Michael,Smolka, Tanja,Sustmann, Reiner,Steller, Ingo,Weiss, Hans-Christoph,Boese, Roland
-
p. 639 - 648
(2007/10/03)
-
- Studies about the cyclization of 1,2-diamines with aldehydes and ketones
-
The reaction of the 1,2-dinucleophile ethylendiamine with benzaldehydes yields diimines, from o-phenylendiamine monoimines respectively benzimidazoles are formed. β-Diketones give 1,5-benzodiazepines. The different behaviour is explained by MNDO calculati
- Lessel
-
p. 649 - 653
(2007/10/02)
-
- Studies on the Oxidation of the Azomethine Compounds with 3-Chloroperbenzoic Acid
-
Oxidation of the azomethine compounds such as Schiff bases and azines having several nucleophilic centers with 3-chloroperbenzoic acid (MCPBA) being an electrophilic oxidant was investigated.From azines 4, bisaldimines 5, 6, and pyridine derived monoaldimines 7, 8, having various substituents on the imine carbon and nitrogen atoms, the products such as nitrones 9, 15, bisoxaziridines 11, 12; acyldiimine 10 and amide 14 were obtained in high yields.The influence of the structure of substrate on the reaction result is discussed.Key words: aldimines, azines, nitrones, oxaziridines
- Mlochowski, J.,Abdel-Latif, F. F.,Kubicz, E.,Said, S. B.
-
p. 711 - 722
(2007/10/02)
-
- Studies on Thiazolidinones. Part-XIV: Synthesis of 3,3'-Bisthiazolidinones and 2,2-Disubstituted Thiazolidinones from Azomethines
-
Several new 3,3'-bisthiazolidinones (III) and 2,2-disubstituted thiazolidinones (VIII) have been synthesised by the cycloadditive dehydration of thioglycolic acid to the azomethin derivatives (II) and (VII) prepared from the aliphatic diamines and heterocyclic monoamines respectively.The structure of the compounds have been confirmed from the spectral data and elemental analysis.The fungicidal and bactericidal activities of the compounds have also been evaluated.
- Sahu, J.,Sahu, T. K.,Naik, S. K.,Nayak, A.
-
p. 861 - 863
(2007/10/02)
-