- Ethyl [...] application of compound and its preparation method (by machine translation)
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The invention discloses ethyl sulfuric acid and its prodrug, solvate or pharmaceutically acceptable salt in the preparation of inflammation, heating, diarrhea, cough and as NF - κB inhibitor pharmaceutical application, its preparation method and composition. (by machine translation)
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Paragraph 0056-0057
(2019/03/15)
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- Preparation method of monoalkyl sulfate
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The invention discloses a preparation method of monoalkyl sulfate. The preparation method comprises that monoalkyl carbonate and dialkyl sulfate undergoes a reaction in a solvent to produce monoalkylsulfate. The preparation method creatively uses monoalkyl carbonate and dialkyl sulfate to synthesize monoalkyl sulfate, the cation structure is not changed before and after the reaction and impurities such as water and halogen elements are not introduced. The monoalkyl phosphate is easy to purify. The preparation method provides a novel approach for preparation of high quality monoalkyl sulfate.
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Paragraph 0050-0051
(2018/04/21)
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- METHOD FOR PRODUCING MONOALKYL SULFATE
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PROBLEM TO BE SOLVED: To provide a method for producing high purity monoalkyl sulfate by reacting dialkyl sulfate and alkali metal salt in an organic solvent. SOLUTION: There is provided the method for producing monoalkyl sulfate by reacting dialkyl sulfate represented by the formula (I) and an alkali metal salt represented by the formula (II). (I) (II), where R represents an alkyl group having 1 to 18 carbon atoms or a haloalkyl group having 1 to 18 carbon atoms, M+ represents a lithium ion, a sodium ion or a potassium ion and X- represents an anion species having a primary acid dissociation constant (pKa1) in a water of conjugate acid thereof of 10. COPYRIGHT: (C)2015,JPOandINPIT
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Paragraph 0043
(2017/08/30)
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- Oxidation-active Flavin Mimics. Chemical and Redox Properties of 7,14-Diethyl-3,10-DimethylbenzoDipteridine-2,4,9,11-(3H,7H,10H,14H)-Tetrone (Benzo-Dipteridine)
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The chemical and redox properties of benzo-dipteridine (BDP), an oxidation-active flavin mimic, were investigated.It was found that (i) BDP undergoes 2e-redox reaction under conventional conditions, (ii) pKa-values of 2e-reduced BDP (BDPred) are 3.6 and 8.5, respectively, (iii) a mixture of BDPox and BDPred forms a charge-transfer complex in aqueous solution, (iv) BDPox exhibits a remarkably high oxidation activity (ca.107-fold) toward reactions involving nucleophilic attack at the C(4a)-position compared with 3,10-dimethylisoalloxazine (DMI), and (v) the oxidation of an NADH model by BDPox is acid-catalysed.As a new model reaction, BDPox was found to oxidize sulphite ion via a BDP-SO3- adduct, which decomposes unimolecularly to give BDPH- and in aqueous solution.This is the first example of an APS (adenosine 5'-phosphosulphate) reductase model.
- Yano, Yumihiko,Nakazato, Michiaki,Iizuka, Kenzo,Hoshino, Tomoko,Tanaka, Kaneichi,et al.
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p. 2179 - 2185
(2007/10/02)
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