cas 54632-11-0, 3-Amino-5-chloropyrazine-2-carbonitrile | Articles data ｜lookchem

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54632-11-0

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Discovery of pyrazol-3-ylamino pyrazines as novel JAK2 inhibitors
The design, synthesis and biological evaluation of a series of pyrazol-3-ylamino pyrazines as potent and selective JAK2 kinase inhibitors is reported, along with the pharmacokinetic and pharmacodynamic properties of lead compounds.
Ioannidis, Stephanos,Lamb, Michelle L.,Davies, Audrey M.,Almeida, Lynsie,Su, Mei,Bebernitz, Geraldine,Ye, Minwei,Bell, Kirsten,Alimzhanov, Marat,Zinda, Michael
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p. 6524 - 6528
(2010/05/18)

PYRAZOLYL-AMINO-SUBSTITUTED PYRAZINES AND THEIR USE FOR THE TREATMENT OF CANCER
The present invention relates to compounds of Formula (I): and to their pharmaceutical compositions, and to their methods of use. These novel compounds provide a treatment for myeloproliferative disorders and cancer.
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Page/Page column 70

(2008/12/04)

More Articles about upstream products of 54632-11-0

42770-07-0
2-amino-3-cyanopyrazine-1-oxide

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Chemical Properties

Melting Point: 194-196oC
Boiling Point: 368.053oC at 760 mmHg
Flash Point:176.393°C
Density: 1.53
Storage Temp.:2-8°C
Vapor Pressure: 0mmHg at 25°C
PKA: -0.87±0.10(Predicted)
PSA: 75.59000
LogP: 1.16508

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