A convenient synthesis of 5β-cholestan-26-oic and 5β-cholestan-26,27-dioic acids
A new method for the preparation of 5β-cholestan-26-oic acids 7 and their analogs is described. The key steps in the synthesis are: iodination of bis- and tris-formyloxy-5β-cholan-24-ols 3; nucleophilic substitution of iodides 4 with diethyl sodiomalonate; complete alkaline hydrolysis of esters 5; and subsequent decarboxylation of geminal diacids 6 in DMSO. Copyright (C) 2000 Elsevier Science Inc.
Starchenkov,Trapencieris,Kauss,Jas,Kalvinsh
p. 143 - 147
(2007/10/03)
Partial synthesis of 25D- and 25L-cholestanoic acids from some common bile acids.
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Briggs
p. 1431 - 1434
(2007/10/15)
Synthesis and metabolism of 5-beta-cholestane-3-alpha, 7-alpha, 12-alpha-triol-26-al. Bile acids and steroids 161.