cas 5539-46-8, 5-aminothiazole-4-carboxamide

5-Aminothiazole-4-carboxamide is a precursor for the synthesis of thiazole [4,5-d] pyrimidines. In this work, a new synthesis method with a high total yield (79%) of 5-aminothiazole-4-carboxamide was reported. The starting material is aminocyanacetamide. This synthesis method is environment-friendly and is suitable for industrial production.

2-Benzylthiazole-4-carboxamide 4 and 5-(β-D-ribofuranosylamino) thiazole-4-carboxamide 10 were synthesized from phenylacetylamino- and formylamino cyanoacetic acid esters 1a and 1b, respectively. The ribosylation reaction leading to 10 gave rise also to i

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Chemical Properties

Melting Point: 140-141 °C

Boiling Point: 366.9±22.0 °C(Predicted)

Density: 1.537

Storage Temp.:2-8°C(protect from light)

PKA: 14.66±0.50(Predicted)

PSA: 110.24000

LogP: 1.10570

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