- Polynuclear nonfused bis(1,3,4-oxadiazole)-containing systems
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Nonfused bis-1,3,4-oxadiazoles were synthesized by reaction of 5-substituted mono- and bis-tetrazoles with mono- and dicarboxylic acid chlorides. The results of kinetic studies showed that the transformation of tetrazoles into 1,3,4-oxadiazoles is accelerated by 1 to 2 orders of magnitude on addition of a catalytic amount of dimethylformamide, triethylamine, or pyridine. Pleiades Publishing, Inc., 2006.
- Vereshchagin,Petrov,Kizhnyaev,Pokatilov,Smirnov
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p. 1049 - 1055
(2007/10/03)
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- High affinity phenylglycinol-based NK1 receptor antagonists
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Heterocyclic replacements for the carboxamido group of the previously disclosed phenylglycinol-based human NK1 (hNK1) receptor antagonists have been investigated, ultimately leading to acyclic compounds with sub-nanomolar affinity for the hNK1 receptor.
- Owens,Harrison,Moseley,Swain,Sadowski,Cascieri
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- 4-Me-1-(2-(1H-tetrazol-5-yl)ethyl)benzene sulfonate and N-2-(1H-tetrazol-5-yl)ethyl methanesulfonamide
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At least one compound defined by one of the following formulae: STR1 where X represents Cl, Br, STR2 or--SCH3, and n is 1 or 2; and have been administered to animals to improve the efficiency of food utilization by these animals. These compounds can be administered orally by combining the compounds with feed compositions and fed to animals such as ruminants with a developed rumen function as well as other animals that ferment fibrous material and vegetable matter in the cecum or colon. These compounds effect the rumen metabolism to increase the production of propionate relative to other volatile fatty acids, particularly acetate and to inhibit methanogenesis.
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- Synthese d'analogues tetrazoles de l'acide phosphonoacetique
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Several routes to 5-(phosphonomethyl)-1(H)-tetrazole, a new antiviral agent, have been investigated.
- Yaouanc,Sturtz,Kraus,Chastel,Colin
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p. 2689 - 2692
(2007/10/02)
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