Aziridine-mediated ligation and site-specific modification of unprotected peptides
A synthesis of aziridine-containing peptides via the Cu(II)-promoted coupling of unprotected peptide thioacids and N-H aziridine-2-carbonyl peptides is reported. The unique reactivity of the resulting N-acylated aziridine-2-carbonyl peptides facilitates t
Dyer, Frank Brock,Park, Chung-Min,Joseph, Ryan,Garner, Philip
supporting information; experimental part
p. 20033 - 20035
(2012/01/31)
Synthesis and NMR spectroscopic studies of optically active derivatives of γ-aminobutenoic acids and 2-amino-pyrrolin-4-ones
An efficient method for the preparation of optically active derivatives of γ-amino-butenoic acids and their cyclic derivatives, 2-amino-pyrrolin-4-ones, from α-amino acids is described. Partial racemization accompanies the formation of initial unsaturated
Petroliagi,Igglessi-Markopoulou
p. 917 - 922
(2007/10/03)
Cathepsin B-sensitive dipeptide prodrugs. 1. A model study of structural requirements for efficient release of doxorubicin
A series of lysosomal protease-sensitive peptides attached to doxorubicin (DOX) was prepared as model substrates for internalizing anticancer immunoconjugates and potential antimetastasis prodrugs. Rates of cathepsin B-mediated release of free drug was measured for each, and human plasma stabilities for representative examples.
Dubowchik, Gene M.,Firestone, Raymond A.
p. 3343 - 3346
(2007/10/03)
ASYMMETRIC SYNTHESIS OF AMINOACIDS BY CATALYTIC REDUCTION OF AZLACTONES OF SUBSTITUTED N-ACYLAMINOACRYLIC ACIDS. COMMUNICATION 15. INFLUENCE OF NUCLEOPHILIC ADDITIVES ON MECHANISM OF REDUCTIVE AMINOLYSIS OF Δ2-OXAZOLIN-5-ONES
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Kaigorodova, L. N.,Levitina, E. S.,Karpeiskaya, E. I.,Klabunovskii, E. I.
p. 747 - 749
(2007/10/02)
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