- PHOSPHODIESTERASE INHIBITORS
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The present invention relates to phosphodiesterase (PDE) type IV selective inhibitors. Compounds disclosed herein can be useful in the treatment of CNS diseases, AIDS, asthma, arthritis, bronchitis, chronic obstructive pulmonary disease (COPD), psoriasis, allergic rhinitis, shock, atopic dermatitis, Crohn's disease, adult respiratory distress syndrome (ARDS), eosinophilic granuloma, allergic conjunctivitis, osteoarthritis, ulcerative colitis and other inflammatory diseases especially in humans. Processes for the preparation of disclosed compounds, pharmaceutical compositions containing the disclosed compounds, and their use as PDE type IV selective inhibitors, are provided.
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Page/Page column 9
(2010/03/02)
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- An efficient method for the preparation of nitriles via the dehydration of aldoximes with phthalic anhydride
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A new and highly efficient method for the conversion of aldoximes to nitriles was established. By fusing with phthalic anhydride, aldoximes were efficiently and smoothly converted into nitriles, in high yields (over 85%) and in a short time (within 5 minutes). The mixture of phthalic anhydride, a cyclic anhydride, and aldoximes in fusing state set up an ideal transition state for a selective [3.3]-sigmatropic rearrangement of the acylated aldoximes to nitriles.
- Wang, Eng-Chi,Huang, Keng-Shiang,Chen, Hsing-Ming,Wu, Chung-Chin,Lin, Gwo-Jiun
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p. 619 - 627
(2007/10/03)
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- A Facile Total Synthesis of (+/-)-Cherylline via an Aziridinium Intermediate
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The 4-aryl-1,2,3,4-tetrahydroisoquinoline alkaloid, (+/-)-cherylline (1), has been synthesised by a ring-opening reaction of the quaternary aziridinium salt, followed by a cyclisation of the quinone methide.
- Kametani, Tetsuji,Higashiyama, Kimio,Honda, Toshio,Otomasu, Hirotaka
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p. 2935 - 2938
(2007/10/02)
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