- Synthesis of isothiocyanates using DMT/NMM/TsO? as a new desulfurization reagent
-
Thirty-three alkyl and aryl isothiocyanates, as well as isothiocyanate derivatives from esters of coded amino acids and from esters of unnatural amino acids (6-aminocaproic, 4-(aminomethyl)benzoic, and tranexamic acids), were synthesized with satisfactory or very good yields (25–97%). Synthesis was performed in a “one-pot”, two-step procedure, in the presence of organic base (Et3 N, DBU or NMM), and carbon disulfide via dithiocarbamates, with 4-(4,6-dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholinium toluene-4-sulfonate (DMT/NMM/TsO? ) as a desulfurization reagent. For the synthesis of aliphatic and aromatic isothiocyanates, reactions were carried out in a microwave reactor, and selected alkyl isothiocyanates were also synthesized in aqueous medium with high yields (72–96%). Isothiocyanate derivatives of L-and D-amino acid methyl esters were synthesized, under conditions without microwave radiation assistance, with low racemization (er 99 > 1), and their absolute configuration was confirmed by circular dichroism. Isothiocyanate derivatives of natural and unnatural amino acids were evaluated for antibacterial activity on E. coli and S. aureus bacterial strains, where the most active was ITC 9e.
- Janczewski, ?ukasz,Kolesińska, Beata,Kr?giel, Dorota
-
-
- Method for jointly preparing isothiocyanate and phosphorus, nitrogen and sulfur flame retardants
-
The invention discloses a method for jointly preparing isothiocyanate and phosphorus, nitrogen and sulfur flame retardants. The method comprises the following steps: taking amine and CS2 as raw materials; generating dithiocarbamate by reacting in a solvent under the existence of alkali; reacting with neopentyl glycol phosphoryl chloride, thereby acquiring an isothiocyanate compound (I); acidizingby-product 1,3,2-phosphorus dioxidehexane thiophosphate (II); generating a salt by reacting with melamine in the solvent, thereby acquiring the phosphorus, nitrogen and sulfur flame retardants (III).According to the method provided by the invention, isothiocyanate and phosphorus, nitrogen and sulfur flame retardants can be jointly prepared; operation is simple and convenient; product yield is high; atom is economical; the prepared phosphorus, nitrogen and sulfur flame retardants (III) have an excellent anti-flaming effect.
- -
-
Paragraph 0014; 0019
(2019/05/22)
-
- T3P - A Benign Desulfurating Reagent in the Synthesis of Isothiocyanates
-
A number of alkyl, aryl and bifunctional isothiocyanates are obtained in moderate to high yields (41-94%) in a two-step, one-pot reaction of the parent primary amines or their salts with carbon disulfide, followed by reaction of the thus formed dithiocarbamates with T3P (propane phosphonic acid anhydride) as a new and efficient desulfurating agent.
- Janczewski, ?ukasz,Gajda, Anna,Frankowski, Sebastian,Goszczyński, Tomasz M.,Gajda, Tadeusz
-
p. 1141 - 1151
(2017/12/06)
-
- A sulfur key Lian Niao multifunctional synergistic antioxidant stabilizer preparation method
-
The invention relates to a preparation method of a multi-functional synergetic anti-oxidative stabilizer for sulfide bond linked urea. The preparation method comprises the following steps: (1) adding organic amine into CS2 and alkali to react; adding meth
- -
-
Paragraph 0043; 0044; 0045; 0046; 0047
(2017/05/12)
-
- A thiourea multifunctional synergistic antioxidant stabilizer and its preparation method and application
-
The invention relates to a multi-functional synergetic anti-oxidative stabilizer for thiourea as well as a preparation method and application thereof. The multi-functional synergetic anti-oxidative stabilizer has a structure shown in the specification, wh
- -
-
Paragraph 0054-0058
(2017/01/31)
-
- ISOTHIOCYANATE PRODUCTION METHOD, COMPOSITION FOR TRANSPORTING AND STORING N-SUBSTITUTED O-SUBSTITUTED THIOCARBAMATE, AND ISOTHIOCYANATE COMPOSITION
-
The present invention relates to an isothiocyanate production method using an organic primary amine and thiourea as starting materials; to a composition for transporting and storing an N-substituted O-substituted thiocarbamate that includes an N-substituted O-substituted thiocarbamate and a hydroxy compound, the equivalent weight ratio of hydroxy groups of the hydroxy compound with respect to the carbamate groups of the N-substituted O-substituted thiocarbamate being in the range of 1 to 100; to a composition for transporting and storing a compound with a thioureido group that includes a compound with a thioureido group and a hydroxy compound, the equivalent weight ratio of hydroxy groups of the hydroxy compound with respect to the thioureido groups of the compound with a thioureido group being in the range of 1 to 100; and to an isothiocyanate composition containing an isothiocyanate and a compound with a specific functional group.
- -
-
-
- ISOTHIOCYANATE COMPOUNDS, PHARMACEUTICAL COMPOSITIONS, AND USES THEREOF
-
Provided herein are compositions of matter and pharmaceutical compositions thereof, for use in inhibiting the growth of various microbial pathogens, including bacteria, fungi, protozoa, and viral pathogens. Also provided herein are methods of treating microbial diseases/infections and cancer with the compositions. The compositions are additionally useful in wood preservation and food preservation by inhibition of microbial growth.
- -
-
Paragraph 0315; 0330
(2015/10/05)
-
- ISOTHIOCYANATE PRODUCTION METHOD, COMPOSITION FOR TRANSPORTING AND STORING N-SUBSTITUTED O-SUBSTITUTED THIOCARBAMATE, AND ISOTHIOCYANATE COMPOSITION
-
The present invention relates to an isothiocyanate production method using an organic primary amine and thiourea as starting materials; to a composition for transporting and storing an N-substituted O-substituted thiocarbamate that includes an N-substituted O-substituted thiocarbamate and a hydroxy compound, the equivalent weight ratio of hydroxy groups of the hydroxy compound with respect to the carbamate groups of the N-substituted O-substituted thiocarbamate being in the range of 1 to 100; to a composition for transporting and storing a compound with a thioureido group that includes a compound with a thioureido group and a hydroxy compound, the equivalent weight ratio of hydroxy groups of the hydroxy compound with respect to the thioureido groups of the compound with a thioureido group being in the range of 1 to 100; and to an isothiocyanate composition containing an isothiocyanate and a compound with a specific functional group.
- -
-
Paragraph 0364; 0365
(2016/10/10)
-
- Influence of linker length in shape recognition of B? DNA by dimeric aminoglycosides
-
Abstract DNA-protein recognition has shown us the importance of DNA shapes in the recognition process. Specific high-affinity targeting of DNA shapes by small molecules is desirable for many biological applications that involve regulation of DNA based pro
- Kumar, Sunil,Spano, Meredith Newby,Arya, Dev P.
-
supporting information
p. 3105 - 3109
(2015/08/03)
-
- SEPARATION METHOD
-
The present invention provides a separation method of separating (A) and (B), comprising: a step of separating at least either an active hydrogen-containing compound (A) or a compound (B) that reversibly reacts with (A) from a mixture containing (A) and (B) by distillation in a multistage distillation column; and a step of supplying the mixture to an inactive region formed within the multistage distillation column.
- -
-
Paragraph 0244-0247
(2013/10/08)
-
- ISOTHIOCYANATE COMPOUNDS, PHARMACEUTICAL COMPOSITIONS, AND USES THEREOF
-
Provided herein are compositions of matter and pharmaceutical compositions thereof, for use in inhibiting the growth of various microbial pathogens, including bacteria, fungi, protozoa, and viral pathogens. Also provided herein are methods of treating microbial diseases/infections and cancer with the compositions. The compositions are additionally useful in wood preservation and food preservation by inhibition of microbial growth.
- -
-
Page/Page column 67; 71-72
(2008/12/07)
-
- Synthesis and biological evaluation of ureido and thioureido derivatives of 2-amino-2-deoxy-D-glucose and related aminoalcohols as N-acetyl-β-D-hexosaminidase inhibitors
-
Ureido and thioureido derivatives of 2-acetamido-2-deoxy-β-D-glucose, 1-amino-1-deoxy-D-glucitol and 2-(2-aminoethoxy)ethanol were prepared as N-acetyl-β-D-hexosaminidase (NAHase) inhibitors and were evaluated on Trichomonas vaginalis NAHase. Although none showed complete inhibition of the enzyme at 100 μM, 1-amino-1-deoxy-D-glucitol derivatives acted as competitive inhibitors of the NAHase of T. vaginalis. Copyright (C) 1998 Elsevier Science Ltd.
- Tournaire-Arellano, Cecile,Younes-El Hage, Salome,Vales, Patricia,Caujolle, Raymond,Sanon, Albertine,Bories, Christian,Loiseau, Philippe M.
-
-