Facile Syntheses of AM-toxins and Analogs as Cyclic Depsipeptides by the Solid-phase Method
The cyclic depsipeptides, AM-toxins I and II and AM-toxin I analogs, were efficiently and rapidly prepared by the Fmoc-based solid-phase method for the synthesis of linear depsipeptides, with N-pyridin-1-ylmethylene>-N-methylmethanaminium hexafluorophosphate N-oxide (HATU) being used for their subsequent cyclization. - Keywords: Am-toxin; host-specific toxin; cyclic depsipeptide; solid-phase synthesis; HATU.
In a search for a more effective route for AM-toxins (cyclic tetradepsipeptides), the syntheses of AM-toxin II as a preliminary peptide and AM-toxin II as a target were attempted.The cyclization of H-L-Ser(Bzl)-L-Ala-L-Hmb-L-Phe-ONSu (Hmb, 2-hydro