- Aurantiamide acetate and fluorinated derivatives thereof as well as preparation method and application thereof
-
The invention belongs to the technical field of medicines, and discloses aurantiamide acetate and fluorinated derivatives thereof, and a preparation method and application thereof. The general formulaof the aurantiamide acetate, the aurantiamide acetate fluorinated derivatives or pharmaceutically acceptable salts of the aurantiamide acetate and the aurantiamide acetate fluorinated derivatives isshown in the specification, wherein R1 represents OH, CH2OH or OCOCH3, and R2, R3 and R4 each independently represent H, an alkyl group or F. The aurantiamide acetate and the fluorinated derivatives or the pharmaceutically acceptable salts thereof have a good effect of preventing or treating influenza viruses, especially infection caused by influenza A viruses. The aurantiamide acetate is subjected to fluorination modification, so that the biological activity of the aurantiamide acetate is stronger. The aurantiamide acetate and the fluorinated derivative thereof act on a target to aim at viruses and also aim at host cells, so that drug resistance is not easy to generate.
- -
-
-
- A DIPEPTIDE DERIVATIVE FROM HYPERICUM JAPONICUM
-
The structure of a novel peptide analogue saropeptate, N-benzoyl-L-phenylalanyl-L-phenylalaninol acetate, isolated from the whole plant of H. japonicum was elucidated by spectroscopic analysis and its absolute configuration determined by comparison with four synthetic diastereoisomers.Key Word Index - Hypericum japonicum; Guttiferae; dipeptide derivative; N-benzoyl-L-phenylalanyl-L-phenylalaninol acetate.
- Ishiguro, Kyoko,Nagata, Satoko,Fukumoto, Hisae,Yamaki, Masae,Takagi, Shuzo,Isoi, Koichiro
-
p. 3639 - 3642
(2007/10/02)
-
- Components of the Chinese drug 'Ti-ku-'pi'. Isolation and establishment of structure of a new dipeptide, lyciumamide
-
A new dipeptide, lyciumamide (1), was isolated from the Chinese crude drug 'Ti-ku-'pi', root bark of Lycium chinense MILL. (Solanaceae), and was shown by spectroscopy, chemical degradation, and synthesis to be N-benzoyl-L-phenylalanyl-L-phenylalaninol O-acetate (1).
- Noguchi,Mochida,Shingu,et al.
-
p. 3584 - 3587
(2007/10/02)
-
- AURANTIAMIDES: A NEW CLASS OF MODIFIED DIPEPTIDES FROM PIPER AURANTIACUM
-
Two new amides, aurantiamide and aurantiamide acetate, were isolated from Piper aurantiacum.Their structures were determined as N-(N'-benzoyl-S-phenylalaninyl)-S-phenylalaninol and its acetate, respectively, from chemical and spectroscopic studies.The structures and stereochemistry were confirmed by synthesis.The corresponding diastereoisomers were also synthesized and their spectroscopic properties compared with those of the natural compounds.Key Word Index- Piper aurantiacum; Piperaceae; seeds; modified dipeptides; aurantiamide, dia-aurantiamide and their acetates.
- Banerji, Avijit,Ray, Rita
-
p. 2217 - 2220
(2007/10/02)
-
