A structure-Permeability study of small drug-like molecules
A systematic structure-permeability relationship study on a set of small drug-like molecules with log D values in the range -2.5 to 3 and carrying a diverse array of functionality reveals that the compounds with log D>0 and 3 are highly permeable. Surprisingly, several tetrazole derivatives were found to be substrates for efflux pump(s).
Fichert, Thomas,Yazdanian, Mehran,Proudfoot, John R.
p. 719 - 722
(2007/10/03)
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