- Discovery of the investigational drug TAK-441, a pyrrolo[3,2-c]pyridine derivative, as a highly potent and orally active hedgehog signaling inhibitor: Modification of the core skeleton for improved solubility
-
We recently reported the discovery of the novel pyrrolo[3,2-c]quinoline-4- one derivative 1 as a potent inhibitor of Hedgehog (Hh) pathway signaling. However, the PK evaluation of 1 at high dosage (100 mg/kg) revealed the C max value 3.63 μg/mL
- Ohashi, Tomohiro,Oguro, Yuya,Tanaka, Toshio,Shiokawa, Zenyu,Tanaka, Yuta,Shibata, Sachio,Sato, Yoshihiko,Yamakawa, Hiroko,Hattori, Harumi,Yamamoto, Yukiko,Kondo, Shigeru,Miyamoto, Maki,Nishihara, Mitsuhiro,Ishimura, Yoshimasa,Tojo, Hideaki,Baba, Atsuo,Sasaki, Satoshi
-
p. 5507 - 5517
(2012/10/30)
-
- 4-hydroxy-2-quinolones. 95. Synthesis, structure, and antitubercular properties of hetarylamides of 4-hydroxy-2-oxo-1,2,5,6,7,8-hexahydroquinoline-3- carboxylic acid
-
The optimal conditions for obtaining hetarylamides of 4-hydroxy-2-oxo-1,2, 5,6,7,8-hexahydroquinoline-3-carboxylic acid are suggested on the basis of derivatographic investigations. The 1H NMR spectra of the synthesized compounds, their spatial
- Ukrainets,Kolesnik,Sidorenko,Gorokhova,Turov
-
p. 765 - 775
(2008/02/04)
-
- An Experimentally Convenient Preparation of Highly Substituted Pyridines
-
A four step sequence is described for the conversion of α,β-unsaturated carboxylic acids into highly substituted pyridines.
- Rigby, James H.,Qabar, Maher
-
p. 2699 - 2709
(2007/10/02)
-
- Tetrahydrocarbostyril derivatives for the prophylaxis of asthma, hayfever and rhinitis
-
Pharmaceutical compositions having anti-allergy activity in which the active anti-allergy agents are certain 3-nitro-α-pyridones and their pharmaceutically acceptable salts formulated in one or more pharmaceutically acceptable carriers.
- -
-
-