- COMPOUNDS FOR THE PREVENTION AND TREATMENT OF CARDIOVASCULAR DISEASES
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The present disclosure relates to compounds, which are useful for regulating the expression of apolipoprotei? A-I (ApoA-l), and their use for the treatment and prevention of cardiovascular disease and related disease states, including cholesterol- or lipid-related disorders, such as, for example, atherosclerosis.
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Page/Page column 94-97
(2008/12/07)
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- A general approach for the synthesis of phenolic natural products. Facile syntheses of grifolin and colletochlorins B and D
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A general approach is established for the synthesis of phenolic compounds having terpenoid side chains: (1) protection of the phenolic hydroxyls in the aromatic precursor by ether formation, (2) coupling the aromatic part with a terpenoid bromide, and (3) deprotection to regenerate the hydroxyl groups. This strategy was successfully applied to the synthesis of colletochlorins B and D and grifolin. Some of the colletochlorin derivatives were found to inhibit the cell growth of P388.
- Saimoto,Ueda,Sashiwa,Shigemasa,Hiyama
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p. 1178 - 1185
(2007/10/02)
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- Aureolic Acid Antibiotics: Synthesis of Naphthocyclobutene Precursors
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The use of the dianion of 1,2-dicarbomethoxycyclobutane, a method introduced by Garrett, has been exploited to produce naphthocyclobutenes with methoxy groups in the naphtho moiety.A highly regioselective functionalization of the cyclobutene ring has been
- Datta, Subhash C.,Franck, Richard W.,Noire, Paul D.
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p. 2785 - 2791
(2007/10/02)
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