- PROCESS FOR PREPARING CEFMETAZOLE SODIUM
-
The present invention relates to a method for manufacturing cefmetazole sodium. More specifically, the present invention relates to a method for manufacturing cefmetazole sodium by crystallization, wherein the method comprises the following steps: dissolving cefmetazole acid and sodium salt in an organic solvent; and then performing crystallization of a product after the reaction by using a crystallization solvent. Thus, the method can manufacture cefmetazole sodium without using lyophilization, which is an existing manufacturing method, while shortening the time and without additional equipment.COPYRIGHT KIPO 2020
- -
-
Paragraph 0034-0041
(2020/09/05)
-
- A head spore US[...] synthesis and purification method
-
The invention discloses a cefmetazole sodium preparation method. The cefmetazole sodium preparation method comprises the following steps: preparing 7beta-chloroacetamide- 7alpha-methoxyl-3-(1-methyl-1H-tetrazole-5-mercaptomethy)-3-cephem-4-carboxylic acid through silanization, halogenation, methoxylation and secondary silanization of 7beta-dichloroacetamido-3-(1-methyl-1H-tetrazole-5-mercaptomethy)-3-cephem-4-carboxylic acid triethylamine salt serving as a starting material, and then carrying out chain extension and acid and salt formation, thus obtaining cefmetazole sodium. The cefmetazole sodium preparation method has the advantages that the yield is high and reaches 55-65%, the product is high in purity, the 7beta-dichloroacetamido-3-(1-methyl-1H-tetrazole-5-mercaptomethy)-3-cephem-4-carboxylic acid triethylamine salt is used for replacing 7-MAC and serves as the starting material, the raw material is convenient in source, low in cost and environmentally friendly, the product is high in purity and suitable for industrial production. and the like.
- -
-
Paragraph 0082; 0087-0090
(2017/02/02)
-
- Preparation method of cefmetazole
-
The invention relates to a preparation method of cefmetazole. The preparation method comprises the steps of adopting a one-pot method containing 7-ACA, 1-methyl-5-tetrazole-thione and chloroacetyl chloride, obtaining 7-DCT, then using seven-position methoxy groups of sodium methylate and tert-butyl hypochlorite, and obtaining methoxy cephalosporin mother nuclei which are shared mother nuclei. The cefmetazole can serve as four methoxy cephalosporin products, namely cefminox, cefmetazole, cephalosporin and cefotetan disodium, three steps are omitted, the processing steps are greatly shortened, cost is lowered, and the overall yield is raised to 70%.
- -
-
-
