- Preparation method of cyclic sulfate
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The invention discloses a preparation method of cyclic sulfate, which is used for preparing cyclic sulfate by a one-step method, and has the beneficial effects that an epoxy compound is used as a rawmaterial to react with sulfamic acid or sulfuric acid in one step under the participation of anhydride to prepare cyclic sulfate, and noble metal catalysis is not needed in the preparation process; corrosive gas production is achieved, the product is high in purity and low in chromaticity (less than 20Hazen), the moisture content is less than or equal to 20ppm, and the acid value is less than or equal to 10ppm, and the influence of moisture and acid value in the electrolyte on the cycle performance and storage stability of the battery is effectively changed.
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Paragraph 0014; 0023-0024
(2021/01/29)
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- Preparation method of ethylene sulfate derivative
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The invention belongs to the technical field of organic synthetic chemistry, and particularly relates to a preparation method of an ethylene sulfate derivative, which comprises the following steps: ina mixed solvent composed of an organic solvent and water, in the presence of alkali and quaternary ammonium salt, by using ruthenium trichloride as a catalyst, reacting to obtain the ethylene sulfatederivative. The ethylene sulfite derivative shown in the general formula A and trichloroisocyanuric acid shown in the formula TCCA are subjected to an oxidation reaction to obtain the ethylene sulfate derivative, and the reaction route is as follows: R1 to R4 are independently a hydrogen atom or an alkyl group of C1-3; the ethylene sulfate derivative is synthesized with high efficiency and low cost, and the yield and purity of the product are improved.
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Paragraph 0033-0034
(2021/01/25)
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- A method for preparing [...] (by machine translation)
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The invention relates to a method for preparing [...], comprising the following steps: S1. The nucleophilic substitution reaction: to propylene glycol and thionyl chloride as the starting material, chloroform as solvent, the nucleophilic substitution reaction, by the sulfurous acid propylene chloroform solution; S2. Oxidation reaction: high iodic acid as the oxidizing agent, the ruthenium trichloride hydrate catalyst, to S1 to obtain solution in the oxidation process is performed on the sulfurous acid propylene shall [...]; S3. The refined purification: sulfuric acid propylene crude soluble in chloroform, under the protection of nitrogen, heating to reflux is fully dissolved, then lower the temperature crystallization, filtering, filters the cake to pass through reduced-pressure drying, to obtain. The mild reaction conditions of the present invention, the synthetic process is simple, easy to operate, high safety, preparation cycle is short, the raw materials used are simple and easy to obtain, the cost is low, few by-products, the preparation of the product has high purity, low water content, low acid value of the product, the product yield is high, and is suitable for industrial production. (by machine translation)
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Paragraph 0023; 0027-0031; 0035-0039; 0043-0046
(2019/05/29)
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- Preparation method of cyclic sulfate
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The invention relates to the field of organic synthesis, in particular to a preparation method of cyclic sulfate. The structural formula of cyclic sulfate is shown as formula I. The preparation methodof cyclic sulfate comprises the following step: cyclic sulfate in the formula I is prepared from a compound in formula II and sulfuryl fluoride by reacting in the presence of an acid binding agent and a catalyst. The preparation method of cyclic sulfate adopts short reaction step, cyclic sulfate can be prepared with the one-step reaction, cost of raw and auxiliary materials is low, and expensiveraw materials and oxidizing agent are not used.
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Paragraph 0078; 0079; 0080; 0081
(2018/03/28)
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- Potent ketoamide inhibitors of HCV NS3 protease derived from quaternized P1 groups
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Blood borne hepatitis C infections are the primary cause for liver cirrhosis and hepatocellular carcinoma. HCV NS3 protease, a pivotal enzyme in the replication cycle of HCV virus has been the primary target for development of new drug candidates. Boceprevir and telaprevir are two novel ketoamide derived inhibitors that are currently undergoing phase-III clinical trials. These inhibitors include ketoamide functionality as serine trap and have an acidic alpha-ketoamide center that undergoes epimerization under physiological conditions. Our initial attempts to arrest this epimerization by introducing quaternary amino acids at P1 had resulted in significantly diminished activity. In this manuscript we describe alpha quaternized P1 group that result in potent inhibitors in the enzyme assay and demonstrate cellular activity comparable to boceprevir.
- Venkatraman, Srikanth,Velazquez, Francisco,Wu, Wanli,Blackman, Melissa,Madison, Vincent,Njoroge, F. George
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scheme or table
p. 2151 - 2155
(2010/06/19)
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- Synthesis of hydroxy sulfonate surfactants
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The selective synthesis of sulfonate surfactants with side chains containing ether- and hydroxy groups was carried out using cyclic sulfates as epoxide analogues. The main chain was elaborated from 1,2-dodecane sulfate by the addition of various hydroxy/alkoxysulfonates. Ethyleneoxy- and 1,2-propyleneoxy- groups were introduced using ethylene sulfate and 1,2-propylene sulfate, respectively.
- Rist, ystein,Carlsen, Per H. J.
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p. 1169 - 1178
(2007/10/03)
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- Total synthesis of (-)-spirotryprostatin B: Synthesis and related studies
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The total synthesis of spirotryprostatin B, a cytostatic spiro[pyrrolidine-3,3′-oxindole] alkaloid, is described. The key step of the synthetic approach consists of the application of the Mgl 2-mediated ring-expansion reaction of a spiro[cyclopropane-1, 3′-oxindole] with an aldimine, leading to rapid assembly of the spirotryprostatin core. The route documents the installation of the prenyl side chain by Julia-Kocienski olefination of a key aldehyde precursor, a transformation that ultimately allows for facile synthesis of analogues and facilitates structure-activity relationships studies.
- Marti, Christiane,Carreira, Erick M.
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p. 11505 - 11515
(2007/10/03)
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- A new route to achiral and chiral 1,2-bis(phosphino)ethanes, 1-arsino-2-phosphinoethanes, and 1,3-bis(phosphino)propanes and the molecular structure and catalytic activity of some rhodium(I) complexes derived thereof
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A series of unsymmetrical 1,2-bis(phosphino)ethanes R2PCH 2CH2PR′2 (2a-d) and 1-arsino-2- phosphinoethanes R2AsCH2CH2PR′ 2 (3a-c) mainly with bulky substituants R and
- Fries, Guido,Wolf, Justin,Ilg, Kerstin,Walfort, Bernhard,Stalke, Dietmar,Werner, Helmut
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p. 1873 - 1881
(2007/10/03)
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- Process for trifluoromethylation of sulfates
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The subject invention relates to a process for the trifluoromethylation of sulfates, including cyclic and acyclic sulfates. The subject invention further pertains to the compounds produced by the trifluoromethylation of sulfates.
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Page/Page column Sheet 2
(2008/06/13)
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- A new route for the synthesis of amphiphilic and water-soluble ligands: Monoand di-tertiary phosphines having an alkylene sulfate chain
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Cyclic sulfates react with LiPPh2 to form a series of new amphiphilic or water-soluble ligands: monotertiary phosphines with one or two alkylene sulfate chains and ditertiary phosphines with one or two hydrophilic tails attached to bridgehead carbon atom; the application of zwitterionic RhI complexes (sulfatephos)2Rh(cod) and (sulfatediphos)Rh(cod) in liquid biphasic catalysis has been demonstrated for the hydroformylation of styrene and oct-1-ene.
- Gulyas, Henrik,Arva, Peter,Bakos, Jozsef
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p. 2385 - 2386
(2007/10/03)
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- Process for the preparation of cyclic sulphates
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STR1 A method for preparing cyclic sulphates having general formula (I), wherein sulphuric anhydride and an alkylene oxide are simultaneously added to the dioxane. In general formula (I), R1, R2, R3 and R4 are the same or different and are a hydrogen atom of a C1-4 alkyl radical optionally substituted by a halogen atom.
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- Process for the preparation of cyclic sulphates
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Cyclic sulphates of formula: STR1 are prepared by oxidation of a cyclic sulphite of formula: STR2 with a hypohalite of an alkali or alkaline-earth metal and a catalytic quantity of a ruthernium derivative (RuO2, RuCl3). In formulae (I) and (II), R1, R2, R3, R4, R5 and R6 are identical or different and each represents hydrogen, halogen, alkyl, alkoxy, aryl, aryloxy or alkoxycarbonyl.
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