- CDPK1 INHIBITORS, COMPOSITIONS, AND METHODS RELATED THERETO
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The invention relates to inhibitors of calcium-dependent protein kinase 1 (CDPK1) and pharmaceutical preparations thereof. The invention further relates to methods of treatment of parasitic infections, such as T. gondii, P. falciparum, C. hominis, or C. parvum infections, using the novel inhibitors of the invention.
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Paragraph 0238-0240
(2021/11/13)
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- Optimizing Pyrazolopyrimidine Inhibitors of Calcium Dependent Protein Kinase 1 for Treatment of Acute and Chronic Toxoplasmosis
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Calcium dependent protein kinase 1 (CDPK1) is an essential Ser/Thr kinase that controls invasion and egress by the protozoan parasite Toxoplasma gondii. The Gly gatekeeper of CDPK1 makes it exquisitely sensitive to inhibition by small molecule 1H-pyrazolo
- Janetka, James W.,Hopper, Allen T.,Yang, Ziping,Barks, Jennifer,Dhason, Mary Savari,Wang, Qiuling,Sibley, L. David
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supporting information
p. 6144 - 6163
(2020/07/10)
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- CDPK1 INHIBITORS, COMPOSITIONS, AND METHODS RELATED THERETO
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The invention relates to inhibitors of calcium-dependent protein kinase 1 (CDPK1 and pharmaceutical preparations thereof. The invention further relates to methods of treatment of parasitic infections, such as T. gondii, P. falciparum, C. hominis, or C. parvum infections, using the novel inhibitors of the invention.
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Page/Page column 54-55
(2019/03/05)
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- CDPK1 INHIBITORS, COMPOSITIONS AND METHODS RELATED THERETO
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The invention relates to inhibitors of calcium-dependent protein kinase 1 (CDPKl) and pharmaceutical preparations thereof. The invention further relates to methods of treatment of parasitic infections, such as T. gondii, T. cruzi, P. falciparum, T. brucei, or L. major infections, using the novel inhibitors of the invention.
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Page/Page column 28; 47
(2018/10/19)
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- A Facile Synthesis of Dialkoxycarbonylketene-, Dicyanoketene-, and Alkoxycarbonyl(cyano)ketene Ethylene Acetals
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Dicyanoketene-, dialkoxycarbonylketene-, and alkoxycarbonyl(cyano)ketene ethylene acetals can be conveniently prepared by reaction of malononitrile, dialkyl malonates and alkyl cyanoacetates with 2-chloroethyl chloroformate.
- Neidlein, Richard,Kikelj, Daniel
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p. 981 - 983
(2007/10/02)
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