- Enhanced copper-mediated 18F-fluorination of aryl boronic esters provides eight radiotracers for PET applications
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[18F]FMTEB, [18F]FPEB, [18F]flumazenil, [18F]DAA1106, [18F]MFBG, [18F]FDOPA, [18F]FMT and [18F]FDA are prepared from the corresponding arylboronic esters and [18
- Preshlock, Sean,Calderwood, Samuel,Verhoog, Stefan,Tredwell, Matthew,Huiban, Mickael,Hienzsch, Antje,Gruber, Stefan,Wilson, Thomas C.,Taylor, Nicholas J.,Cailly, Thomas,Schedler, Michael,Collier, Thomas Lee,Passchier, Jan,Smits, René,Mollitor, Jan,Hoepping, Alexander,Mueller, Marco,Genicot, Christophe,Mercier, Jo?l,Gouverneur, Véronique
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p. 8361 - 8364
(2016/07/07)
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- IDO INHIBITORS
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There are disclosed compounds of formula (I) that modulate or inhibit the enzymatic activity of indoleamine 2,3-dioxygenase (IDO), pharmaceutical compositions containing said compounds and methods of treating proliferative disorders, such as cancer, viral infections and/or inflammatory disorders utilizing the compounds of the invention.
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Page/Page column 57; 61
(2015/01/16)
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- Microwave-assisted synthesis of nonsymmetrical aryl ethers using nitro-arenes
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An efficient, microwave-assisted ligand-free, catalyst-free synthetic method for nonsymmetrical diaryl ethers has been developed by using nitroarenes. A variety of phenols and nitroarenes was scanned by using this method to produce nonsymmetrical aryl ethers. The newly developed method is an ecofriendly and cost-effective approach to synthesize nonsymmetrical aryl ethers.
- Sarkate, Aniket P.,Bahekar, Sushilkumar S.,Wadhai, Vijay M.,Ghandge, Ganesh N.,Wakte, Pravin S.,Shinde, Devanand B.
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p. 1513 - 1516
(2013/08/23)
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- N-(5-fluoro-2-phenoxyphenyl)-N-(2-[131I]iodo-5-methoxybenzyl) acetamide: A potent iodinated radioligand for the peripheral-type benzodiazepine receptor in brain
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To image the peripheral-type benzodiazepine receptor (PBR) in vivo, we previously developed two positron emission tomography (PET) ligands, N-(2-[ 11C],5-dimethoxybenzyl)-N-(5-fluoro-2-phenoxyphenyl)acetamide ([ 11C]1a) and its [sup
- Zhang, Ming-Rong,Kumata, Katsushi,Maeda, Jun,Haradahira, Terushi,Noguchi, Junko,Suhara, Tetsuya,Halldin, Christer,Suzuki, Kazutoshi
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p. 848 - 855
(2007/10/03)
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- NON-STEROIDAL PROGESTERONE RECEPTOR MODULATORS
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The present invention provides compounds according to general Formula (I), a prodrug thereof, a pharmaceutically acceptable salt thereof, or a pharmaceutically acceptable salt of a prodrug thereof. More particularly, the present invention provides high affinity non-steroidal compounds which are agonists, partial agonists or antagonists of the progesterone receptor.
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Page/Page column 52
(2010/02/07)
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