- A 2 - substituted - 1, 3 - dithiane derivative of the preparation method
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The invention provides a preparation method of a 2-substituted-1,3-dithiane derivative. The preparation method comprises the following steps: adding 1,3-dithiane (CAS:505-23-7) and 1,2-dichloroethane (DCE) or dichloromethane (DCM) into a reaction bottle, adding N-chlorosuccinimide (NCS) under ice-bath condition, and stirring for 0.5-1 h to prepare a 2-chloro-1,3-dithiane solution; and adding an aldehyde or ketone compound and a lewis acid catalyst into the above solution, and reacting to prepare the 2-substituted-1,3-dithiane derivative. By using the 1,3-dithiane solid and different types of aldehyde and keto-carbonyl compounds as raw material and using one or more of ferric trichloride, boron trifluoride diethyl etherate, methanesulfonic acid, aluminum trichloride, ferrous chloride and nickel chloride as catalysts, preparation of the 2-substituted-1,3-dithiane derivative is realized. The catalysts used in the invention are cheap and easily available, dosage of the catalysts is low and pollution of the catalysts is little. The solid raw materials used in the invention can avoid use of fetid toxic 1,3-dimercaptopropane with strong volatility, and the purpose of protecting an experimenter's body and reducing environmental pollution is realized. In addition, the preparation method has advantages of mild reaction condition, high yield, simple operation and the like.
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Paragraph 0023; 0024; 0025; 0026; 0027
(2019/06/26)
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- Nazarov cyclization of divinyl and arylvinyl epoxides: Application in the synthesis of resveratrol-based natural products
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New variation in the Nazarov cyclization has been developed by preparing divinyl and arylvinyl epoxides as pentadienyl cation precursors for the first time. Highly substituted cyclopentadienes, hydrindienes, and indenes were synthesized to demonstrate the compatibility of this reaction with substrates bearing a variety of substitutions and having different types of epoxides. Application of this method in the synthesis of resveratrol-based natural products was also demonstrated.
- Sudhakar, Gangarajula,Satish, Kovela
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supporting information
p. 6475 - 6480
(2015/04/22)
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- An efficient, continuous flow technique for the chemoselective synthesis of thioacetals
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By optimizing a reagent's residence time within a packed-bed reactor, it is possible to overcome selectivity issues frequently encountered in stirred reaction vessels. This important feature is demonstrated for the chemoselective protection of 4-acetylben
- Wiles, Charlotte,Watts, Paul,Haswell, Stephen J.
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p. 7362 - 7365
(2008/03/13)
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- A Simple and Efficient Synthesis of Chiral Acetic Acid of High Optical Purity
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(R)- and (S)-2H,2-3H>acetic acid of high chiral purity was synthesized in over 50 percent radiochemical yield.Reduction of 3,5-dimethoxy-2H>benzaldehyde with optically pure (+)-α-pinanyl-9-BBN and reduction of the un
- Kobayashi, Koji,Prabhakar, K. Jadhav,Zydowsky, Thomas M.,Floss, Heinz G.
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p. 3510 - 3512
(2007/10/02)
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- Development of a Strategy for Convergent Total Synthesis of the Aureolic Acid Antitumor Antibiotics
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It has been found that condensation of an o-toluate carbanion with a 3-alkoxycyclohexen-2-one will produce the dihydroanthracenone system found in olivin (3) and chromomycinone (4), the aglycons of the aureolic acids.Several examples of this reaction are described, leading to synthesis of model aromatic systems 17, 18, 21, 23, 24, and 26.A route to compound 34, having the complete carbon framework and most of the functionality of olivin, has been developed which uses the above type of condensation as the critical step.
- Dodd, John H.,Garigipati, Ravi S.,Weinreb, Steven M.
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p. 4045 - 4049
(2007/10/02)
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