- An efficient catalytic method for the Beckmann rearrangement of ketoximes to amides and aldoximes to nitriles mediated by propylphosphonic anhydride (T3P)
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An efficient method for the Beckmann rearrangement of ketoximes to amides mediated by a catalytic amount (15 mol %) of propylphosphonic anhydride (T3P) is described. Aldoximes underwent second order Beckmann rearrangement to provide the corresponding nitriles in excellent yields on reacting with T3P (15 mol %) at room temperature. The main advantages of this environmentally friendly protocol include procedural simplicity, and particularly ease of isolation of the products.
- Augustine, John Kallikat,Kumar, Rajesha,Bombrun, Agnes,Mandal, Ashis Baran
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scheme or table
p. 1074 - 1077
(2011/03/22)
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- Propylphosphonic anhydride (T3P): A remarkably efficient reagent for the one-pot transformation of aromatic, heteroaromatic, and aliphatic aldehydes to nitriles
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Propylphosphonic anhydride has been demonstrated to be an efficient reagent for the transformation of aromatic, heteroaromatic, and aliphatic aldehydes to respective nitriles in excellent yields. This procedure offers simple and one-pot access to nitriles and highlights the synthetic utility of T3P as a versatile reagent in organic chemistry. Georg Thieme Verlag Stuttgart - New York.
- Augustine, John Kallikat,Atta, Rajendra Nath,Ramappa, Balakrishna Kolathur,Boodappa, Chandrakantha
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experimental part
p. 3378 - 3382
(2010/03/03)
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- Novel domino reactions for diterpene synthesis
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New types of concerted domino acylation-cycloalkylation/alkylation- cycloacylation reactions have been described. These processes promoted by methanesulfonic acid-phosphorus pentoxide and concentrated H2SO 4, respectively, provide efficient, elegant, and expeditious routes for biologically active naturally occurring diterpenoids, namely (±)-ferruginol (1), (±)-nimbidiol (2), (±)-nimbiol (3), (±)-totarol (4), and ar-abietatriene (5).
- Bhar, Shanta S.,Ramana
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p. 8935 - 8937
(2007/10/03)
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- CATIONIC CYCLIZATION OF GERANONITRILE AND RELATED COMPOUNDS VIA THEIR BROMOHYDRINS: APPLICATION TO THE SYNTHESIS OF (+/-)-SNYDEROLS
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Cationic cyclization of bromohydrins of geranonitrile and homogeranonitrile in the presence of boron trifluoride complexes proceeded smoothly, giving mixtures of bromo cyclic olefins in satisfactory yields.This cyclization method was applied to the synthesis of (+/-)-snyderols.
- Murai, Akio,Abiko, Atsushi,Kato, Koji,Masamune, Tadashi
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p. 1125 - 1128
(2007/10/02)
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