- A chromium picolinate synthetic method (by machine translation)
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The invention discloses a synthetic method of chromium picolinate; the method comprises the steps of: adding 2-cyanopyridine into methanol or ethanol for dissolution, and then adding NaOH or KOH water solution; reacting for 1 hour, adding water and controlling temperature, adjusting pH value to 8-9; dropping potassium chromium sulfate water solution at 50-70 DEG C; stirring, cooling and pumping filtrating, and washing and drying filtered products so as to obtain the chromium picolinate. Because the 2-cyanopyridine is resolved in homogeneous for reaction, so only one hour is needed for hydrolyzation, thereby greatly reducing reaction time; the product is in rose color, good in fluidity, crystal form is hexagon; because complexation reaction employs chromic salt potassium chromium sulfate, so the obtained chromium picolinate is high in purity; the purity can reach 99.8% and above, and total impurity is smaller than 0.5%, thereby solving high energy consumption, high danger and high production equipment requirement problems caused by high temperature and high pressure reaction, and removing safety troubles brought by usage of sodium dichromate; the method is short in technology reaction time, simple in process, technology process is easy to control, production yield is high, crystal form is good and purity is high, and industrialization production can be realized.
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Paragraph 0014; 0026; 0027
(2017/02/09)
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- Triazolopyridines. Part 27.1 the preparation of novel 6,7-dihydro[1,2,3] triazolo[1,5-a]pyridines
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A very efficient synthesis of the unknown family of 6,7-dihydro[1,2,3] triazolo[1,5-α]pyridines from [1,2,3]triazolo[1,5-α]pyridines have been developed, and a mechanism for their formation has been proposed. Their behaviour with NBS to give 4,5-dibromo substituted-4,5,6,7-tetrahydro-[1,2,3] triazolo[1,5-α]pyridines is studied.
- Abarca, Belen,Adam, Rosa,Ballesteros, Rafael
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experimental part
p. 319 - 327
(2010/08/19)
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