- Synthesis of 3-amino-3-vinylpropanoic acid and its conversion to 4-amino-5-hydroxy-4,5-dihydrofuran-2-one hydrochloride (HAD), a cyclic stabilised form of aspartate 1-semialdehyde hydrochloride
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3-amino-3-vinylpropanoic acid hydrochloride 4 was obtained from 4-acetoxyazetidin-2-one 1 in 3 steps. The ozonolysis of 4 yielded 3-amino-4-oxopropanoic acid hydrochloride (aspartate 1-semialdehyde hydrochloride 6). This labile α-aminoaldehyde is isolated
- Cheung, Kwai-Ming,Shoolingin-Jordan, Peter M.
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- Method for preparation of sphingoid bases
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The present invention provides a series of non-toxic compounds which function to inhibit the activity of S-1-P aldolase in respect to its cleavage of S-1-P. These inhibitors are described by the compounds of formula I STR1 wherein R is a radical containing 1 to 15 carbon atoms, a halogen, or hydrocarbon, R' is an organic radical or hydrogen, and R" is --NH3+ or --NH--NH +, with the proviso that, when R is CH3 (CH)12 (CH=CH) and R' is hydrogen, R" is --NH--NH3+. A method for preparing such compounds, which may generally be described as 1-phosphate derivatives of compounds which include a 2-amino-1,3-alcohol radical is also disclosed.
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