- Cyhalofop-containing pesticide composition and application thereof
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The invention discloses a pesticide composition containing cyhalofop-butyl and application thereof, belongs to the technical field of pesticide preparation and comprises 10 - 20 parts of cyhalofop-butyl. Tetramethyl chloride 3-5 parts, synergistic microcapsule 8-13 parts, wetting agent 1.5 - 4.5 parts, dispersing agent 1-3 parts, defoaming agent 0.5 - 1.5 parts and water 40 - 50 parts. When the water in the soil is less, the weed is absorbed by the chitosan so as to accelerate the absorption of A the synergic microcapsule and the cyhalofop-butyl ester, so that the pesticide composition is greatly reduced per mu.
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- Studies on the structure and biosynthesis of tridentoquinone and related meroterpenoids from the mushroom Suillus tridentinus (Boletales)
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Tridentoquinone (1), the main pigment of Suillus tridentinus, is accompanied by the known meroterpenoid bolegrevilol (3) and a dimer, tridentorubin (5). The absolute configuration of 1 was unambiguously established by a single-crystal X-ray analysis of the corresponding (-)-camphanoate. The structure of 5 was elucidated by 2D NMR techniques including a 2D INADEQUATE experiment. Feeding experiments with [1-13C]-labeled 4-hydroxybenzoic acid (6*) and 3,4-dihydroxybenzoic acid (7*) proved the incorporation of these precursors into all three metabolites. Tridentoquinone (1) was monolabeled at C-1 suggesting the formation of the ansa ring by oxidative cyclisation of 2-geranylgeranyl-6-hydroxybenzoquinone (10). This was supported by the isolation of the expected intermediate, deoxytridentoquinone (11), from the mushroom extract. Tridentorubin (5) may be formed by addition of precursor 10 to tridentoquinone (1). This hypothesis is backed up by the in vitro formation of an analogous product 13 from 1 and 1,4-benzoquinone. Wiley-VCH Verlag GmbH & Co. KGaA, 2008.
- Lang, Martin,Muehlbauer, Andrea,Graef, Claudia,Beyer, Juergen,Lang-Fugmann, Susanne,Polborn, Kurt,Steglich, Wolfgang
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experimental part
p. 816 - 825
(2009/04/11)
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- BICYCLIC COMPOUNDS USEFUL AS CATHEPSIN S INBHIBITORS
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Compounds of formula (I), wherein R1, R2, R3, Ra and E are are defined within, and pharmaceutically acceptable salts, solvates, hydrates and N-oxides thereof having utility in the treatment of disorders mediated by cathepsin S.
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Page/Page column 39
(2010/11/29)
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- CATHEPSIN S INHIBITORS
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Compounds of the formula (I) where R1 is C1-C4 straight or branched alkyl, optionally substituted with up to three substituents selected from halo and hydroxy; R2 is halo, hydroxy, methyloxy, or C1-C2 alkyl, which alkyl is optionally substituted with up to three halogens or an hydroxy or a methyloxy; D is - C3-C7 alkylene-, thereby defining a cycloalkyl ring; E is -C(=O)-, -S(=O)m-, -NRdS(=O)m-, -NRaC(=O)-, -OC(=O)-, R3 is an optionally substituted carbocyclic or heterocyclic ring R10 is H, ORc, SRc or together with the gem H is =O or (ORc)2; Ra is independently selected from H, C1-C4 alkyl; have utility in the inhibition of cathepsin S and are thus useful pharmaceuticals against disorders such as autoimmune disorders and chronic pain.
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Page/Page column 93-94
(2010/11/08)
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- METHOD OF CONJUGATING AMINOTHIOL CONTAINING MOLECULES TO VEHICLES
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The present invention relates to a novel chemical process that provides novel vehicle derivatives that are exceptional 1,2- or 1,3-aminothiol specific reagents for conjugation to unprotected targeted compounds (e.g., polypeptides, peptides, or organic compounds) having or modified to have a 1,2- or 1,3 aminothiol group. The invention further relates to the methods of using novel water-soluble polymer derivatives and conjugates thereof.
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Page/Page column 68; 69
(2008/06/13)
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- Aminoalkoxybenzoyl-benzofuran or benzothiophene derivatives, method of preparing same and compositions containing same
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Benzothiophenes and related compounds of formula (1), wherein A, B, Z are independently —CH═, —CR4═ or ═N—; X is —S—, —O—, —NH—, —NR2, —CH2—CH2—, CH2—CH2—CH2—, —CH2—O—; —OCH2—, —CH2—S—, —CO—, —SCH2—. —N═CR2— or —R2C═N—; Y is optionally substituted phenyl, alkyl, cycloalkyl, cycloalkenyl, heterocycle or bicyclic ring system; D is —CO—, CR2R3—, —CONH—, —NHCO—, —CR2(OH)—, —CONR2, NOR1 CH—NO2 N—CN —NR2—CO—, —C—, —C—, —C—; E is a single bond, optionally substituted phenyl, heterocycle; Z1 is —(CH2)p W(CH2)q—, —O(CH2)p CR5R6— or —O(CH2)p W(CH2)q; G is —NR7R8, (a), (b), (c), a 5- or 6-membered saturated, unsaturated or partially unsaturated and optionally substituted heterocycle or a bicyclic amine containing 5 to 12 carbon atoms either bridged or fused and optionally substituted and R is halogen, —NR2R3, —NHCOR2, —NHSO2R2, —CR2R3OH, —CONR2R3, —SO2NR2R3, OH, —OR1, —O—COR1; are estrogen agonists which are useful for treating syndromes and diseases caused by estrogen deficiency.
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- Hydroxyethylamino sulphonamides useful as retroviral protease inhibitors
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PCT No. PCT/US94/09139 Sec. 371 Date Jan. 24, 1996 Sec. 102(e) Date Jan. 24, 1996 PCT Filed Aug. 23, 1994 PCT Pub. No. WO95/06030 PCT Pub. Date Mar. 2, 1995The invention relates to sulfonamide-containing hydroxyethylamine protease inhibitor compounds, their process of making, composition and method of use for inhibiting retroviral proteases such as human immunodeficiency virus.
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- Reimer-Thiemann reaction using carbon tetrachloride
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The title reaction has been carried out on the three isomeric cresols, thymol and 3,4-dimethylphenol, and the phenolic carboxylic acids so obtained have been characterised.
- Gaonkar, A. V.,Kirtany, J. K.
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p. 800 - 801
(2007/10/02)
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- Synthesis of Substitued Dibenzophospholes. Part 6. Preparation of Symmetrical and Non-symmetrical Quaterphenyl Intermediates
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Further examples are given of the synthetic approach to 4,6-diaryldibenzophospholes by arylation of 1,3-dinitrobenzene and coupling of the resulting biphenyls to symmetrically substituted quaterphenyls.Satisfactory procedures are described for the monoarylation of 2,2',4,4'-tetranitrobiphenyl and for arylation of the products to provide non-symmetrically substituted tetranitroquaterphenyls.Some procedures for the regioselective alkoxydenitration of tetranitroquaterphenyls are described.
- Cornforth, Sir John,Kumar, Ashok,Stuart, Alan S.
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p. 859 - 866
(2007/10/02)
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- Synthesis of 4-Hydroxy-2-methylbenzoic Acid and Its Higher Homologues
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Synthesis of 4-hydroxy-2-methylbenzoic acid (1a) and its higher homologues such as 4-hydroxy-2-methylphenylacetic acid (1b), 3-(4-hydroxy-2-methylphenyl)propanoic acid (1c) and 4-(4-hydroxy-2-methylphenyl)butanoic acid (1d) are described.
- Sen, P. K.,Pal, Panchanan,Goswami, Shyamaprosad,Chattopadhyay, Gautam
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p. 679 - 682
(2007/10/02)
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- SELECTIVE SYNTHESES USING CYCLODEXTRINS AS CATALYSTS. 2. PARA-ORIENTED CARBOXYLATION OF PHENOLS.
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4-Hydroxybenzoic acid and 4-hydroxy-3-methylbenzoic acid are synthesized in virtually 100% selectivities and high yields from the corresponding phenols and carbon tetrachloride by using beta -cyclodextrin ( beta -CD) as catalyst. The selective syntheses are successfully achieved by a small molar ratio, even 0. 03, of beta -CD to phenols and are hardly suppressed by oxygen. Kinetic study shows that the selective catalyses by beta -CO originate from both promotion of the para carboxylation and almost complete inhibition of the ortho carboxylation. Heptakis(2,6-di-0-methyl) beta -cyclodextrin in contrast decreases the para selectivity, showing the importance of the hydroxyl groups of beta -CD in its selective catalysis. The selective catalysis by beta -CD proceeds via formation of a molecular complex with the active species, probably the trichloromethyl cation.
- Komiyama,Hirai
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p. 174 - 178
(2007/10/02)
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- Novel liquid crystal compounds and electro-optic devices incorporating them
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Liquid crystal compounds of the formula STR1 wherein X can be alkyl (R-), alkoxy (RO-), acyloxy STR2 or alkylcarbonato STR3 wherein R is an alkyl group from 1-10 carbon atoms, and R1 -R3 can be hydrogen, methyl or halogen with the proviso that at least one and no more than two of R1 -R3 are substituents other than hydrogen, have positive dielectric anisotropy and are useful in electro-optic devices which comprise a thin liquid crystal layer between two closely spaced parallel electrodes.
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