- Synthesis method of L-penicillamine hydrochloride
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The invention relates to a synthesis method of L-penicillamine hydrochloride, and mainly solves the technical problems that the existing synthesis method has harsh reaction conditions and is not suitable for large-scale production. The synthesis method comprises the following steps: carrying out reflux reaction on D-penicillamine in an acetic acid/acetone system to generate a compound 1; reacting the compound 1 with acetyl chloride in a tetrahydrofuran solution by taking triethylamine as alkali to generate a compound 2; salifying the compound 2 and (D)-(+)-1-phenylethylamine in an acetone solution to generate a compound 3; dissociating the compound 3 with diluted hydrochloric acid to generate a compound 4; and hydrolyzing the compound 4 in a hydrochloric acid aqueous solution to generate a target compound 5. The method has the advantages of mild reaction conditions, simple operation and high yield, and is suitable for industrial production.
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Paragraph 0008
(2021/08/28)
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- ESTERS OF NON- AROMATIC HETEROCYCLIC COMPOUNDS HAVING A NEMATOCIDAL ACTIVITY, THEIR AGRONOMIC COMPOSITIONS AND USE THEREOF.
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Non-aromatic fluoroalkenyl heterocyclic compounds having general formula (I), agronomic compositions containing said compounds having formula (I) and their use for the control of nematodes in agricultural crops, are described.
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Page/Page column 66
(2020/11/12)
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- NOVEL FLUORESCENT DYES AND USES THEREOF
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The present invention provides fluorescent dyes that are based on firefly luciferin structure. These dyes are optimally excited at shorter wavelengths and have Stokes shift of at least 50 nm. The fluorescent dyes of the invention are useful for preparation of dye-conjugates, which can be used in detection of an analyte in a sample.
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Page/Page column 34
(2011/02/24)
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- Gas/Solid Reactions with Acetone
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Gas/solid reactions of acetone vapor with neutral organic compounds, salts, or host crystals with strict exclusion of solvents are reported.This gas/solid technique largely avoids waste formation and saves resources.Starting hydrochlorides or hydrobromides are also synthesized by gas/solid techniques.Dihydrohalides of o-phenylenediamines give 1,5-benzodiazepines 3, aromatic and aliphatic 1,2-aminothiols (o-aminothiophenol, penicillamines, cysteine) yield five-membered thiazolines and thiazolidines 7, 9, 11, 13.Virtually all carbonyl reagents of the primary amino type 14 give quantitatively the imino derivatives 15 and water.Salt formation may be helpful for increasing melting points and sometimes reactivity as in 8, 10, and 12 if surface passivation has to be overcome.In the case of solid 14 the free bases react equally well.Acetone (2) may be quantitatively removed from exhaust gases by using hydroxylaminium phosphate with formation of free acetone oxime at high flow rates.Inclusion of acetone into various hosts (17-20, but not 16) is more efficient by imbibition from the gas phase than by crystallization from acetone as the solvent.This advantage may be utilized for gas separations.Some further gases (vapors) coexist in imbibed clathrates whereas others do not.The mechanisms of the gas/solid reactions are elucidated using atomic force microscopy (AFM).Phase rebuildings involve anisotropic movements of molecules over large distances and the formation of characteristic features.In some cases surface hydrates catalyze the gas/solid reaction.Solid-state mechanisms for imbibition from the gas phase into host crystals with formation of clathrates are similar in nature to those of the covalent reactions.These results are correlated with known X-ray crystal structures where available. - Key Words: Gas/solid reactions / Imbibition / Acetone derivatives / Atomic force microscopy / Anisotropic phase rebuilding / Waste prevention
- Kaupp, Gerd,Pogodda, Uwe,Schmeyers, Jens
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p. 2249 - 2262
(2007/10/02)
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- Process of making penicillamine
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Penicillamine and its hydrochloride are made by reacting isobutyraldehyde with elemental sulfur or a sulfur-containing compound and with gaseous ammonia so as to form 2-isopropyl-5.5-dimethyl-thiazoline-Δ3, then reacting the latter compound with substantially anhydrous hydrogen cyanide so as to form the corresponding thiazolidine 4-carbonitrile, thereupon treating the latter compound with an excess of concentrated hydrochloric acid at an elevated temperature and separating the components of the mixture formed and recovering the penicillamine hydrochloride which may then be converted to the free D,L-penicillamine.
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- Process for the resolution of D,L-penicillamine and salts formed during said process
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D,L-penicillamine is separated into its antipodes employing optically active threo-1-(p-nitrophenyl)-2-aminopropanediol-1,3.
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