- K2S as Sulfur Source and DMSO as Carbon Source for the Synthesis of 2-Unsubstituted Benzothiazoles
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We describe a three-component reaction of o-iodoanilines with K2S and DMSO that provides 2-unsubstituted benzothiazoles in moderate to good isolated yields with good functional group tolerance. Electron-rich aromatic amines and o-phenylenediamines instead of o-iodoanilines provided 2-unsubstituted benzothiazoles and 2-unsubstituted benzimidazoles with and without K2S under similar conditions. Notably, DMSO plays three vital roles: carbon source, solvent, and oxidant.
- Deng, Guobo,Kuang, Daizhi,Liang, Yun,Yang, Yuan,Yu, Jiangxi,Zhang, Fuxing,Zhu, Xiaoming
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supporting information
p. 3789 - 3793
(2020/06/04)
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- Method for synthesizing benzothiazole compound by taking halogen-free aromatic amine as substrate
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The invention discloses a method for synthesizing a benzothiazole compound by taking halogen-free aromatic amine as a substrate. The synthesis method comprises the following steps: adding an aromaticamine compound, potassium sulfide, dimethyl sulfoxide, an additive 1 and an additive 2 into a reaction tube, carrying out a stirring reaction at 120-150 DEG C, cooling to room temperature after the reaction is finished, and separating and purifying the product to obtain the benzothiazole compound. According to the reaction, an aromatic amine compound is used as a substrate, sulfuration as a sulfursource and dimethyl sulfoxide as a carbon source, the reaction conditions are relatively mild, and a metal catalyst is not needed. The invention develops the method for synthesizing the benzothiazolecompound, which is simple to operate and economical in atom.
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Paragraph 0027-0029
(2020/11/09)
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