Intramolecular C(sp3)-N coupling by oxidation of benzylic C,N-dianions
What a couple! An intramolecular, C(sp3)-N coupling to afford azacycles is reported. This reaction proceeds through the oxidation of benzylic C,N-dianions with iodine and builds on an earlier discovery during the synthesis of the natural produc
A facile synthesis of 6-alkyl-6,7-dihydro-5H-dibenz[c,e]azepines: Potent hypolipidemics
6-Alkyl-6,7-dihydro-5H-dibenz[c,e]azepines were synthesized in two steps in 63-88% overall yield by utilizing an efficient borane-tetrahydrofuran reduction of imides.
Akula,Kabalka
p. 3901 - 3906
(2007/10/03)
Hypolipidemic activity of 6-substituted 6,7-dihydro-5H-dibenz[c,e]azepine and the effects of 6,7-dihydro-5H-dibenz[c,e]azepine on lipid metabolism of rodents
A series of 6-substituted derivatives of 6,7-dihydro-5H-dibenz[c,e]azepine was found to be active hypolipidemic agents in rodents at doses of mg/kg per day. The parent drug was found to suppress the enzyme activity of ATP-dependent citrate lyase, sn-glyce
Hall,Murthy,Wyrick
p. 622 - 626
(2007/10/02)
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