cas 58476-59-8, N-(4-broMophenyl)-2-nitrobenzenaMine

Articles about 58476-59-8Total 38 be found

Article title
Article abstract
Author
Journal number and time
Download

Benzimidazolone derivatives organic light emitting compound and organic electroluminescent device including the same
Provided is a benzo imidazolone derivative organic electroluminescent compound represented by chemical formula a. Chemical Formula a. The benzo imidazolone derivative organic light emitting compound is suitable for inclusion in an organic electroluminescent device. Both electrochemical stability and thermal stability can be satisfactorily met.
-
Paragraph 0093-0097

(2021/04/20)

Deuterium atom-containing electron transport material and application thereof
The invention discloses a deuterium atom-containing electron transport material and an application thereof. The deuterium atom-containing electron transport material is a benzimidazole compound with a deuterated substituent, and can be used as an electron transport material in an electroluminescent device. The novel compounds enable the organic electroluminescent device to be improved in efficiency and achieve longer device life, and better device performance can be provided. An electroluminescent device and a compound formulation are also disclosed.
-
Paragraph 0157-0160

(2021/11/10)

Compound containing polyheterocycles and application
The invention relates to the technical field of organic electroluminescent display, particularly discloses an organic material containing a polyheterocyclic compound, and also discloses an applicationof the organic material in an organic electroluminescent device. The polyheterocycle-containing compound provided by the invention is shown as a general formula (I), can be applied to the field of organic electroluminescence, and can be used as an electron transport material. The compound with the structure provided by the invention is applied to an OLED device, the driving voltage of the devicecan be reduced, and the light emitting efficiency of the device is improved.
-
Paragraph 0061-0063; 0099-0102

(2020/10/20)

A green and practical reduction of N-(4-chlorophenyl)-2-nitroaniline and its derivatives to corresponding N-substituted-benzene-1,2-diamines using thiourea dioxide
A new effective approach for synthesizing diverse N-substituted-benzene-1,2-diamines is reported. The treatment of N-substituted-2-nitroanilines with thiourea dioxide in the presence of sodium hydroxide efficiently formed the corresponding N-substituted-benzene-1,2-diamines, including N-(4-chlorophenyl)benzene-1,2-diamine with a good yield of 94%. The by-product is environmentally-friendly urea and is easy to separate from the product by filtration procedure that enhances the convenience of the approach.
Cui, Jian-Lan,Wang, Ning,Wang, Xiao,Yu, Si-Yuan,Zhong, Cong-Shan
supporting information

(2020/01/22)

Polyheterocyclic compound and application
The invention relates to the technical field of organic electroluminescent display, particularly discloses an organic material of a polyheterocyclic compound, and also discloses application of the organic material in an organic electroluminescent device. The polyheterocyclic compound provided by the invention is shown as a general formula (I), can be applied to the field of organic electroluminescence, and is used as a luminescent layer main body material. The compound with the structure provided by the invention is applied to an OLED device, and can reduce the driving voltage and improve thelight emitting efficiency of the device.
-
Paragraph 0042-0047; 0069-0074

(2020/10/04)

Design, synthesis and biological evaluation of novel 4-phenoxypyridine based 3-oxo-3,4-dihydroquinoxaline-2-carboxamide derivatives as potential c-Met kinase inhibitors
Blocking c-Met kinase activity by small-molecule inhibitors has been identified as a promising approach for the treatment of cancers. Herein, we described the design, synthesis, and biological evaluation of a series of 4-phenoxypyridine-based 3-oxo-3,4-dihydroquinoxaline derivatives as c-Met kinase inhibitors. Inhibitory activitives against c-Met kinase evaluation indicated that most of compounds showed excellent c-Met kinase activity in vitro, and IC50 values of ten compounds (23a, 23e, 23f, 23l, 23r, 23s, 23v, 23w, 23x and 23y) were less than 10.00 nM. Notably, three of them (23v, 23w and 23y) showed remarkable potency with IC50 values of 2.31 nM, 1.91 nM and 2.44 nM, respectively, and thus they were more potent than positive control drug foretinib (c-Met, IC50 = 2.53 nM). Cytotoxic evaluation indicated the most promising compound 23w showed remarkable cytotoxicity against A549, H460 and HT-29 cell lines with IC50 values of 1.57 μM, 0.94 μM and 0.65 μM, respectively. Furthermore, the acridine orange/ethidium bromide (AO/EB) staining, cell apoptosis assays by flow cytometry, wound-healing assays and transwell migration assays on HT-29 and/or A549 cells of 23w were performed. Especially compound 23w, which displayed potent antitumor, apoptosis induction and antimetastatic activity, could be used as a promising lead for further development. Meanwhile, their preliminary structure-activity relationships (SARs) were also discussed.
Wang, Zhen,Shi, Jiantao,Zhu, Xianglong,Zhao, Wenwen,Gong, Yilin,Hao, Xuechen,Hou, Yunlei,Liu, Yajing,Ding, Shi,Liu, Ju,Chen, Ye
(2020/10/21)

Bipyridyl derivative and application thereof
The present invention provides a novel compound, which has a structure general formula represented by a formula (I), wherein Ar1 and Ar2 are independently selected from an aromatic hydrocarbon derivative group containing benzimidazoyl, an aromatic hydrocarbon derivative group containing a pyridine group, substituted or unsubstituted C6-C30 aromatic hydrocarbon, and a substituted or unsubstituted C6-C30 fused ring aromatic hydrocarbon group, and R1 and R2 are independently and respectively selected from H, C1-C12 aliphatic hydrocarbon radical, phenyl, substituted phenyl, naphthyl, substituted naphthyl, biphenyl and substituted biphenyl. According to the present invention, the compound has characteristics of stable character, simple preparation process, high luminous efficiency and high carrier mobility, and can be used for the electron transport layer of the electroluminescent element, and the device applying the compound has characteristics of significant driving voltage reducing and current efficiency improving. The formula (I) is defined in the instruction.
-
Paragraph 0042-0046

(2019/08/06)

Selenium-Catalyzed Carbonylative Synthesis of 2-Benzimidazolones from 2-Nitroanilines with TFBen as the CO Source
A selenium-catalyzed carbonylative reaction for the synthesis of 2-benzimidazolones from 2-nitroanilines has been developed. In this strategy, to avoid the usage of toxic CO gas, TFBen (benzene-1,3,5-triyl triformate) was used as a solid and stable CO precursor, and a variety of desired 2-benzimidazolones were produced in moderate to excellent yields.
Qi, Xinxin,Zhou, Rong,Peng, Jin-Bao,Ying, Jun,Wu, Xiao-Feng
supporting information
p. 5161 - 5164
(2019/01/25)

Organometallic Ir(III) Phosphors Decorated by Carbazole/Diphenylphosphoryl Units for Efficient Solution-Processable OLEDs with Low Efficiency Roll-Offs
Recently, solution-processable PhOLEDs have been attracting great interest for their low cost and high productivity relative to the vacuum-deposited devices. Similar to vacuum-deposited OLEDs, however, they usually suffer from serious efficiency roll-offs, especially in high brightness. Finding a feasible way and/or designing novel materials to increase efficiencies and reduce roll-offs simultaneously are highly desired. Herein, a new family of solution-processable cyclometalated iridium(III) phosphors with carbazole (Cz) and/or diphenylphosphoryl (Ph2PO) units functionalized main ligands has been designed. Owing to Cz and Ph2PO moieties possessing bulky steric effects, they can suppress the intermolecular strong packing and then decrease TTA effects and emission quenching. Meanwhile, the resulting OLEDs based on the designed phosphors exhibit considerable efficiencies and relatively small efficiency roll-offs. The device based on 4 containing both Cz and Ph2PO units realized a maximum current efficiency of 21.3 cd A-1, accompanied by a small roll-off. By optimization of the configuration of OLEDs, the device performance can be further enhanced, demonstrating their potential for high-performance solution-processable PhOLEDs.
Song, Wei-Lin,Mao, Hui-Ting,Shan, Guo-Gang,Gao, Ying,Cheng, Gang,Su, Zhong-Min
supporting information
p. 13807 - 13814
(2019/10/14)

Derivative of benzimidazole bridging anthracenes as well as preparation method and application thereof
The invention belongs to the technical field of photoelectric material application science and technology, and particularly relates to a derivative of benzimidazole bridging anthracenes as well as a preparation method and application thereof. According to the derivative of the benzimidazole bridging anthracenes, the derivative of the benzimidazole bridging anthracenes is used as basic structure unit, and is then modified to obtain an asymmetric structure. The compound provided by the invention has high glass transition temperature and high electron transmission capacity. When used as an electron transmission material and compared with a conventional main body material of an electron transmission group, such as a conventional electron transmission material 1,3,5-tri(1-phenyl-1H-benzimidazole-2-group) benzene (TPBi), the compound has the advantages that the hole transmission capacity and the electron transmission capacity are obviously improved; in an organic electroluminescence device,when compared with the conventional electron transmission material, the compound has the advantages that the glass transition temperature, the current efficiency, the power efficiency, the external quantum efficiency, the slow down efficiency and the roll-off aspect are obviously improved, and is an ideal electron transmission material.
-
Paragraph 0054-0056

(2018/03/24)

ORGANIC LIGHT EMITTING DEVICE AND PREPARATION METHOD THEREOF
The present invention relates to a display technical field, especially to an organic light emitting device which includes from the bottom to the top: a substrate, an anode layer, a hole injection layer, a hole transport layer, an exciton blocking layer, an organic light emitting layer, an electron transport layer, an electron injection layer and a cathode layer; the material of the organic light emitting layer includes benzimidazole derivative as illustrated in Formula 1, wherein P1, P2 and P3 are benzene rings, and at least one of R1?R12 is a substituent having hole transport ability. The present invention further provides preparing methods for the organic light emitting layer and device.
-
Paragraph 0056; 0058; 0059; 0060

(2018/12/02)

Compound for organic optoelectronic device, organic light emitting diode including the same and display including the organic light emitting diode
A compound for an organic optoelectronic device is represented by Chemical Formula 1: and, in Chemical Formula 1, one of Ar1 or Ar2 is a substituted or unsubstituted C6 to C30 aryl group, or a substituted or unsubstituted C3 to C30 heteroaryl group, and the other of Ar1 or Ar2 is a substituent represented by the Chemical Formula 2:
-
Page/Page column 80; 82

(2017/02/09)

Design, synthesis and biological evaluation of novel 4-phenoxyquinoline derivatives containing 3-oxo-3,4-dihydroquinoxaline moiety as c-Met kinase inhibitors
A series of novel 4-phenoxyquinoline derivatives containing 3-oxo-3,4-dihydroquinoxaline moiety were synthesized and evaluated for their c-Met kinase inhibitory activity and antiproliferative activity against five cancer cell lines (HT-29, H460, A549, MKN-45 and U87MG) in vitro. Most of the compounds exhibited moderate-to-significant cytotoxicity as compared with foretinib. The most promising compound 41 (with c-Met IC50 value of 0.90?nM) showed remarkable cytotoxicity against HT-29, H460, A549, MKN-45 and U87MG cell lines with IC50 values of 0.06?μM, 0.05?μM, 0.18?μM, 0.023?μM and 0.66?μM, respectively, and thus it was 1.22- to 3.50-fold more potent than foretinib. Their preliminary structure-activity relationships (SARs) studies indicate that electron-withdrawing groups on the terminal phenyl rings are beneficial for improving the antitumor activity.
Liu, Ju,Yang, Di,Yang, Xiuxiu,Nie, Minhua,Wu, Guodong,Wang, Zhunchao,Li, Wei,Liu, Yajing,Gong, Ping
p. 4475 - 4486
(2017/07/22)

Preparation method and application of phenylbenzimidazole based monopole thermal exciting delayed fluorescence body and electronic transmission material
The invention provides a method and application of a phenylbenzimidazole based monopole thermal exciting delayed fluorescence body and an electronic transmission material, relates to the synthesizing and application of organic electroluminescence thermal exciting delayed fluorescence body and an electronic transmission material, belongs to the field of preparation of bodies and electronic transmission materials, and aims at solving the technical problems of complicated process in preparation of the conventional multi-layer complex blue-light OLED device and high device cost. The phenylbenzimidazole based monopole thermal exciting delayed fluorescence body electronic transmission material is characterized in that phenylbenzimidazole is used as the base body. The material synthesized by the method is treated as the body material and the electronic transmission; the four-layer simplified device structure is able to effectively improve the device performance; the carrier injection and transmission capacity of an electroluminescent device material can be improved; the external quantum efficiency of a thermal exciting delayed fluorescence devices prepared through the phenylbenzimidazole based monopole thermal exciting delayed fluorescence body and the electronic transmission material is 12.5%; the thermodynamic stability is high; the cracking temperature is beyond 380 DEG C; meanwhile, the luminous efficiency and the brightness of the organic electroluminescence material can be improved. The material is mainly applied to an organic thermal exciting delayed fluorescent diode pipe.
-
Paragraph 0158; 0159

(2017/08/29)

Design, synthesis and antifungal activity of novel fenfuram-diarylamine hybrids
Ten novel fenfuram-diarylamine hybrids were designed and synthesized. And their antifungal activities against four phytopathogenic fungi have been evaluated in vitro and most of the compounds demonstrated a significant antifungal activities against Rhizoctonia solani and Sclerotinia sclerotiorum. Compound 5e exhibited the most potent antifungal activity against R. solani with an EC50value of 0.037 mg/L, far superior to the commercially available fungicide boscalid (EC50= 1.71 mg/L) and lead fungicide fenfuram (EC50= 6.18 mg/L). Furthermore, scanning electron microscopy images showed that the mycelia on treated media grew abnormally with tenuous, wizened and overlapping colonies compared to the negative control. Molecular docking studies revealed that compound 5e featured a higher affinity for succinate dehydrogenase (SDH) than fenfuram. Furthermore, it was shown that the 3-chlorophenyl group in compound 5e formed a CH-π interaction with B/Trp-206 and a Cl-π interaction with D/Tyr-128, rendering compound 5e more active than fenfuram against SDH.
Wang, Hongyu,Gao, Xuheng,Zhang, Xiaoxiao,Jin, Hong,Tao, Ke,Hou, Taiping
supporting information
p. 90 - 93
(2016/12/09)

Synthesis and biological evaluation of novel pyrazole carboxamide with diarylamine-modi?ed scaffold as potent antifungal agents
Twenty-seven novel pyrazole carboxamides with diarylamine-modi?ed scaffold were designed, synthesized and characterized in detail via 1H NMR, 13C NMR, IR and ESI-HRMS. Preliminary bioassays showed that some of the target compounds exhibited good antifungal activity against Rhizoctonia solani, Rhizoctonia cerealis and Sclerotinia sclerotiorum. Among them, compound 9c-7 exhibited the highest antifungal activities against R. solani, R. cerealis and S. sclerotiorum in vitro with IC50 values of 0.013, 1.608 and 1.874?μg/mL, respectively. Notably, compound 9c-7 still presented the highest fungicidal activities against R. solani in vivo with an IC50 value of 22.21?μg/mL. Molecular docking simulation results reveal that compound 9c-7 binds well to the hydrophobic pockets of the receptor protein succinate dehydrogenase. This study suggests that compound 9c-7 could act as a potential fungicide to be used for further optimization.
Zhang, Xiao-Xiao,Jin, Hong,Deng, Yuan-Jie,Gao, Xu-Heng,Li, Yong,Zhao, Yong-Tian,Tao, Ke,Hou, Tai-Ping
p. 1731 - 1736
(2017/07/27)

Boron-containig benzopyrenes derivatives, their preparation and organic electroluminescent device (by machine translation)
The present invention relates to a 6-tritolyl-6H-6-bora benzo[cd]pyrene derivative represented by a formula (1), wherein substituents are described in an instruction. The present invention further relates to uses of the compound as an electron transportation material, and an organic electroluminescent device containing the compound. Formula (1).
-
Paragraph 0104; 0105

(2016/10/07)

Heterocyclic compound and organic light emitting device comprising same
Provided is an organic light emitting device which uses an aryl amine derivative using benzimidazole as a framework for a light emitting layer, thereby having high efficiency and long life. Disclosed are a heterocyclic compound represented by chemical formula 1 and an organic light emitting device comprising the same. Refer to detailed description on substituents of the chemical formula 1.
-
Paragraph 0231-0235

(2016/10/17)

6,12-DINAPHTHYLCHRYSENE DERIVATIVE AND ORGANIC LIGHT-EMITTING DEVICE USING THE DERIVATIVE
Provided are an organic compound having high heat stability suitable for use in an organic light-emitting device, and an organic light-emitting device using the organic compound. The organic light-emitting device is an organic light-emitting device, including: an anode; a cathode; and an organic compound layer disposed between the anode and the cathode, in which at least one layer of the organic compound layer has a 6,12-dinaphthylchrysene derivative represented by one of the following general formulae (1) and (2): in the formulae (1) and (2), Z represents a naphthyl group, and Q represents an electron-withdrawing substituent selected from the group consisting of the following general formulae (3) to (5): in the formula (5), R 1 represents a hydrogen atom or a methyl group.
-
Paragraph 0128-0131

(2016/11/21)

Binaphthalene bridged bipolar transporting materials for blue electroluminescence: Toward high EL efficiency via molecular tuning
Two isomeric bipolar transporting molecules containing arylamine and benzimidazole moieties linked by 1,1-binaphthalene bridge have been synthesized and used for blue light-emitting diodes. The highly twisted binaphthalene bridge is beneficial for amorphous morphology, good solubility, high thermal stability and high photoluminescence quantum efficiency (ΦPL). The charge transfer bands of these compounds exhibit interesting solvent-polarity dependent fluorescence properties. The physical properties of the compounds were tunable upon binding of the benzimidazole with binaphthalene group via C- (BINAPC) or N- (BINAPN) linkage. Three-layered blue-emitting OLEDs using BINAPC or BINAPN as the emitting layer, NPB as the hole transporting layer, and TPBI as the electron transporting layer as well as hole-blocking layer exhibit good performance. External quantum efficiencies of 2.49% with color coordinates of (0.15, 0.11) and 2.67% with color coordinates of (0.16, 0.16) were achieved for BINAPC and BINAPN, respectively.
Muangpaisal, Rossatorn,Hung, Wei-I.,Lin, Jiann T.,Ting, San-Yu,Chen, Li-Yin
supporting information
p. 2992 - 2998
(2014/04/17)

NOVEL FUSED POLYCYCLIC COMPOUND AND ORGANIC LIGHT-EMITTING DEVICE, DISPLAY APPARATUS, IMAGE INFORMATION PROCESSING APPARATUS, LIGHTING SYSTEM, AND IMAGE FORMING APPARATUS HAVING THE COMPOUND
A novel organic compound suitable for blue-light-emitting devices and an organic light-emitting device including the compound are provided. An organic compound represented by Formula [1] according to Claim 1 is provided. In Formula [1], R1 to R16 each independently represent a group selected from a hydrogen atom, a cyano group, substituted or unsubstituted alkyl groups, substituted or unsubstituted aryl groups, and substituted or unsubstituted heterocyclic groups.
-
Paragraph 0173-0174

(2014/03/21)

Efficient deep-blue emitters based on triphenylamine-linked benzimidazole derivatives for nondoped fluorescent organic light-emitting diodes
Two triphenylamine-substituted benzimidazole derivatives were synthesized for use as efficient deep-blue emitters in nondoped fluorescent organic light-emitting diodes (FLOLEDs). The molecular design of 40,40 0-(1H-benzo[d]imidazole-1,2-diyl)bis(N,N-diphenylbiphenyl-4-amine) (T2B) to limit the molecular packing density enabled T2B-based devices to suppress the exciton quenching by a bulky three-dimensional structure. Nondoped FLOLEDs fabricated using T2B as a blue emitter exhibited an external quantum efficiency of 4.67% with color coordinates of (0.15, 0.08).
Jeong, Seongjin,Kim, Myoung-Ki,Kim, Sung Hyun,Hong, Jong-In
p. 2497 - 2504
(2013/10/22)

"All-water" one-pot diverse synthesis of 1,2-disubstituted benzimidazoles: Hydrogen bond driven 'synergistic electrophile-nucleophile dual activation' by water
A new "all-water" tandem arylaminoarylation/arylaminoalkylation- reduction-cyclisation route is reported for one-pot diversity oriented synthesis of regiodefined 1,2-disubstituted benzimidazoles. Water plays a crucial and indispensable role through hydrogen bond driven 'synergistic electrophile-nucleophile dual activation' in the formation of N-mono-aryl/aryl alkyl/alkyl/cycloalkyl o-nitroanilines under metal and base-free conditions to replace the transition metal-based C-N bond formation (aryl amination) chemistry and underlines the origin of regiodefined installation of the diverse selection of aryl, aryl alkyl, and alkyl/cycloalkyl groups as substituents on the benzimidazole scaffold to form the 1,2-disubstituted benzimidazoles. The influence of the hydrogen bond effect of water in promoting the arylaminoarylation reaction under base and metal-free conditions has been realized through observation of inferior yields in D2O compared to that obtained in water during the reaction of o-fluoronitrobenzene with aniline separately performed in water and D2O under similar experimental conditions. Water also provides assistance in promoting the subsequent nitro reduction and in the final cyclocondensation steps. The role of water in promoting the cyclocondensation reaction through hydrogen bonds is realized by the differential product yields during the reaction of mono-N-phenyl-o- phenylenediamine with benzaldehyde performed separately in water and D 2O. The better hydrogen bond donor and hydrogen bond acceptor abilities of water compared to those of the organic solvents are the contributing/deciding factors for making the new water-assisted tandem arylaminoarylation/arylaminoalkylation-reduction-cyclisation strategy for the diversified synthesis of the regiodefined 1,2-disubstituted benzimidazoles effective in an aqueous medium, making it represent a true "all-water chemistry."
Kommi, Damodara N.,Jadhavar, Pradeep S.,Kumar, Dinesh,Chakraborti, Asit K.
p. 798 - 810
(2013/04/24)

NITROGENATED HETEROCYCLIC RING DERIVATIVE AND ORGANIC ELECTROLUMINESCENT ELEMENT COMPRISING SAME
A nitrogen-containing heterocyclic derivative represented by the following formula (1): wherein any "12-a" groups of R1 to R12 are independently a hydrogen atom, a fluorine atom, a substituted or unsubstituted aryl group having 6 to 30 ring carbon atoms or a substituted or unsubstituted heterocyclic group having 5 to 30 ring atoms; any "a" groups of R1 to R12 are independently a single bond which is bonded to L1; L1 is a single bond, a "b+1" valent substituted or unsubstituted hydrocarbon ring group having 6 to 30 ring carbon atoms or a "b+1" valent substituted or unsubstituted heterocyclic group having 5 to 30 ring atoms; HAr is a substituted or unsubstituted nitrogen-containing heterocyclic group; and "a" and "b" are independently an integer of 1 to 4, and at least one of "a" and "b" is 1. Also disclosed is a nitrogen-containing heterocyclic derivative represented by the following formula (21) or (31):
-
Page/Page column 31

(2012/12/13)

Fused polycyclic compound and organic light-emitting device using the compound
Provided are fused polycyclic compounds suitable for use mainly as a component for a blue-light-emitting device, and an organic light-emitting device using the compound. The fused polycyclic compounds are represented by the general formulae (1), (2), (8) and (9).
-
Page/Page column 28-29

(2012/12/14)

Identification of less lipophilic riminophenazine derivatives for the treatment of drug-resistant tuberculosis
Clofazimine (CFZ), a member of the riminophenazine class, has been studied in clinical trials for the treatment of multidrug-resistant tuberculosis (MDR-TB). CFZ has several side effects which can be attributed to its extremely high lipophilicity. A series of novel riminophenazine analogues bearing a C-2 pyridyl substituent was designed and synthesized with the goal of maintaining potent activity against Mycobacterium tuberculosis (M. tuberculosis) while improving upon its safety profile by lowering the lipophilicity. All compounds were evaluated for their in vitro activity and cytotoxicity. The results demonstrated that many new compounds had potent activity against M. tuberculosis with MICs of less than 0.03 μg/mL and low cytotoxicity with IC50 values greater than 64 μg/mL. Some compounds were tested for in vivo efficacy against MDR-TB in an experimental mouse infection model. Two compounds demonstrated equivalent or better efficacy than CFZ in this model with significantly reduced skin discoloration potential.
Zhang, Dongfeng,Liu, Kai,Liu, Binna,Wang, Jingbin,Zhang, Gang,Zhang, Hao,Liu, Yang,Hou, Yanyan,Gong, Ningbo,Lv, Yang,Li, Chun,Yin, Dali,Huang, Haihong,Lu, Yu,Wang, Bin,Zheng, Meiqin,Fu, Lei,Cooper, Christopher B.,Upton, Anna M.,Ma, Zhenkun
p. 8409 - 8417,9
(2020/09/15)

BIPHENYL SUBSTITUTED 1,3-DIHYDRO-BENZOIMIDAZOL-2-YLIDENEAMINE DERIVATIVES
The invention relates to new derivatives of formula (I), wherein the substituents are as defined in the specification; to processes for the preparation of such derivatives; pharmaceutical compositions comprising such derivatives; such derivatives as a medicament; such derivatives for the treatment of one or more IGF-1R mediated disorders or diseases
-
Page/Page column 47-48

(2012/01/06)

N -aryl chromophore ligands for bright europium luminescence
Sterically hindered N-aryl-benzimidazole pyridine-2-carboxylic acids (aryl = phenyl, 4-biphenyl, 2-naphthyl) readily form homoleptic, neutral, nine-coordinate europium complexes which display efficient sensitized luminescence in solid state and in dichloromethane solution with quantum yields reaching 59% and have monoexponential and nearly temperature-independent lifetimes as long as 2.7 ms. The ligand-centered absorption band with a maximum at 321-342 nm and intensity (50-56) - 103 M-1cm -1 ensures efficient harvesting of excitation light by the complexes. Variation of N-aryl chromophore enhances the ligand absorption at 250-350 nm without changing its triplet state energy which amounts to (19.2-21.3) × 103 cm-1. Photophysical properties of europium complexes benefit from adequate protection of the metal by the ligands against non-radiative deactivation and efficient ligand-to-metal energy transfer exceeding 70%. A correlation is observed between the sensitized luminescence quantum yields of europium and the ligand triplet state energy; in certain cases it points to the presence of a second-sphere quenching of EuIII by co-crystallized water in the solid state.
Shavaleev, Nail M.,Eliseeva, Svetlana V.,Scopelliti, Rosario,Buenzli, Jean-Claude G.
experimental part
p. 3927 - 3936
(2010/06/14)

NITROGEN-CONTAINING HETEROCYCLIC DERIVATIVE AND ORGANIC ELECTROLUMINESCENT DEVICE USING THE SAME
A novel nitrogen-containing heterocyclic derivative having a specific structure. An organic electroluminescence device comprises an organic thin-film layer which is disposed between a cathode and an anode and comprises one or more layers having a light emitting layer. At least one layer of the organic thin-film layer comprises the nitrogen-containing heterocyclic derivative. The organic electroluminescence device exhibits a high luminance and a high luminous efficiency even at a low driving voltage.
-
Page/Page column 37-38

(2010/10/19)

PIPERIDINE DERIVATIVES AS HUMAN PAPILLOMA VIRUS INHIBITORS
HPV inhibitors with formula (I) where G1 represents a hydrocarbonated bond or chain possibly substituted by one or two alkyl groups, G2 represents a group (see formula Ia+Ib) or R represents a hydrogen, an alkyl, halogenoalkyl, or a prodrug radical such as carbamate, acetyl or dialkylaminomethyl, G represents a bond or a hydrocarbonated chain possibly substituted by one or two alkyls, W represents an oxygen or sulphur, R1 and R2 each represent a group chosen from among hydrogen, halogen, hydroxyl, thio, alkoxy, halogenoalkoxy, alkylthio, halogenoalkylthio, amino, monoalkylamino, dialkylamino, cycloalkyl, alkyl or halogenoalkyl, R3 represents an acid or a prodrug radical of the acid function or a bioisostere of the acid function, A represents an aryl, cycloalkyl, cycloalkenyl or a heterocycle, each possibly substituted, and B represents an aryl or a heterocycle with 6 chains, each possibly substituted, and pharmaceutically acceptable salts.
-
Page/Page column 22

(2009/09/05)

NITROGENOUS HETEROCYCLE DERIVATIVE AND ORGANIC ELECTROLUMINESCENT ELEMENT EMPLOYING THE SAME
Provided is a material for an organic EL device realizing an organic EL device capable of having a high current efficiency even at a low voltage. Provided is a derivative of heterocyclic compound having a nitrogen atom represented by the following general formula (A-1) or (A-2). In the formulae, R 1a to R 5a each represent a substituent, Ar 1a to Ar 3a each represent a single bond or a divalent connecting group, and HAr represents a group represented by a general formula (A-3) or (A-4). R 6a to R 10a each represent a substituent.
-
Page/Page column 46

(2008/06/13)

A versatile and efficient ligand for copper-catalyzed formation of C-N, C-O, and P-C bonds: Pyrrolidine-2-phosphonic acid phenyl monoester
A new and readily available bidentate ligand, namely, pyrrolidine-2- phosphonic acid phenyl monoester (PPAPM), has been developed for the copper-catalyzed formation of C-N, C-O, and P-C bonds, and various N-, O-, and P-arylation products were synthesized in good to excellent yields by using the CuI/PPAPM catalyst system. Addition of the PPAPM ligand greatly increases the reactivity of the copper catalyst, and the resulting versatile and efficient catalyst system is of widespread and practical application in cross-coupling reactions.
Rao, Honghua,Jin, Ying,Fu, Hua,Jiang, Yuyang,Zhao, Yufen
p. 3636 - 3646
(2008/02/03)

An inexpensive and efficient copper catalyst for N-arylation of amines, amides and nitrogen-containing heterocycles
An inexpensive and efficient catalyst system has been developed for the N-arylation of nitrogen-containing compounds including a variety of amines, amides, indole and imidazole. This simple protocol uses CuI as the catalyst, commercial available pipecolinic acid as the new ligand, K2CO 3 as the base and DMF as the solvent.
Guo, Xun,Rao, Honghua,Fu, Hua,Jiang, Yuyang,Zhao, Yufen
p. 2197 - 2202
(2007/10/03)

NITROGEN-CONTAINING HETEROCYCLE DERIVATIVE AND ORGANIC ELECTROLUMINESCENT ELEMENT USING THE SAME
A novel derivative of heterocyclic compound having nitrogen atom with a structure made by bonding special groups to benzimidazole, a material for an organic electroluminescence (EL) device comprising the derivative of heterocyclic compound having nitrogen atom and an organic electroluminescence device comprising at least one organic compound layer containing a light emitting layer sandwiched between a pair of electrodes, wherein the device contains the derivative of heterocyclic compound having nitrogen atom. An organic EL device achieving elevation of luminance and of efficiency in light emission even under low driving voltage is obtainable by an employment of the derivative of heterocyclic compound having nitrogen atom for at least one layer composing organic compound layers of the EL device.
-
Page/Page column 35

(2010/02/14)

An efficient and fast procedure for the preparation of 2-nitrophenylamines under microwave conditions
2-Nitrophenylamines were prepared in good yields from 2-chloronitrobenzen (or 2-fluoronitrobenzene) and amines in the presence of anhydrous potassium fluoride under microwave irradiation and solvent free conditions.
Xu, Zhi-Bin,Lu, Ying,Guo, Zong-Ru
p. 564 - 566
(2007/10/03)

An improved synthesis of N-substituted-2-nitroanilines
The reaction of 2-chloronitrobenzene with substituted amines/ anilines in the presence of DBU (1,8-diazabicyclo[5.4.0]undec-7-ene) gives N-substituted-2-nitroanilines in good to excellent yields (>75-90%).
Chauhan,Singh, Ram,Geetanjali
p. 2899 - 2906
(2007/10/03)

Regulation of retinoidal actions by diazepinylbenzoic acids. Retinoid synergists which activate the RXR-RAR heterodimers
In human HL-60 promyelocytic leukemia cells, diazepinylbenzoic acid derivatives can exhibit either antagonistic or synergistic effects on the differentiation-inducing activities of natural or synthetic retinoids, the activity depending largely on the nature of the substituents on the diazepine ring. Thus, a benzolog of the retinoid antagonist LE135 (6), 4-(13H- 10,11,12,13-tetrahydro-10,10,13,13,15-pentamethyldinaphtho[2,3-b][1,2- e]diazepin-7-yl)benzoic acid (LE540, 17), exhibits a 1 order of magnitude higher antagonistic potential than the parental LE135 (6). In contrast, 4- [5H-2,3-(2,5-dimethyl-2,5-hexano)-5-methyldibenzo[b,e][1,4]diazepin-11-yl]- benzoic acid (HX600, 7), a structural isomer of the antagonistic LE135 (6), enhanced HL-60 cell differentiation induced by RAR agonists, such as Am80 (2). This synergistic effect was further increased for a thiazepine, HX630 (29), and an azepine derivative, HX640 (30); both synergized with Am80 (2) more potently than HX600 (7). Notably, the negative and positive effects of the azepine derivatives on retinoidal actions can be related to their RAR- antagonistic and RXR-agonistic properties, respectively, in the context of the RAR-RXR heterodimer.
Umemiya, Hiroki,Fukasawa, Hiroshi,Ebisawa, Masayuki,Eyrolles, Laurence,Kawachi, Emiko,Eisenmann, Ghislaine,Gronemeyer, Hinrich,Hashimoto, Yuichi,Shudo, Koichi,Kagechika, Hiroyuki
p. 4222 - 4234
(2007/10/03)

New Modified Preparation of 2-Nitrodiarylamines
2-Nitrodiarylamines are prepared in good yields from 2-chloronitrobenzene and anilines in the presence of potassium fluoride without solvent at 160-170 deg C.
Zhu, Yun-Fei,Lin, Guo-Qiang,Chen, Yu-Qun
p. 430
(2007/10/02)