- New hexamethine indothia-cyanines: Synthesis and photophysical properties as well as both antitumor activity and imaging
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Six new hexamethine indothia-cyanines were successfully synthesized by integrating a benzothiazole or naphthothiazole and indole unit using isophorone. These cyanines exhibited strong absorption and near-infrared fluorescence with a large stokes shift, and showed excellent stability. And they were tested as novel anticancer agents in vitro against human breast cancer cells (MCF-7), and indothia-cyanine D1 could efficiently reduce MCF-7 viability and exhibited no toxicity against normal human immortalized epidermal cells (Hacat). Cyanine D1 was further studied for its antitumor activity in mice. The in vivo result indicated that D1 could significantly inhibit the growth of breast tumors from tumor-bearing mice, and had no effect on the normal functions of the vital organs in vivo. In addition, D1 could stain MCF-7 cells and emitted bright red fluorescence, being a potential functional agent with both imaging and antitumor activity.
- Deng, Wenting,Wang, Lanying,Wang, Yunxia,Zhao, Junlong,Jia, Hongliang
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- Facile Incorporation of Pd(PPh3)2Hal Substituents into Polymethines, Merocyanines, and Perylene Diimides as a Means of Suppressing Intermolecular Interactions
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Compounds with polarizable π systems that are susceptible to attack with nucleophiles at C-Hal (Hal = Cl, Br) bonds react with Pd(PPh3)4 to yield net oxidative addition. X-ray structures show that the resulting Pd(PPh3)2Hal groups greatly reduce intermolecular π-π interactions. The Pd-functionalized dyes generally exhibit solution-like absorption spectra in films, whereas their Hal analogues exhibit features attributable to aggregation.
- Davydenko, Iryna,Barlow, Stephen,Sharma, Rajesh,Benis, Sepehr,Simon, Janos,Allen, Taylor G.,Cooper, Matthew W.,Khrustalev, Victor,Jucov, Evgheni V.,Casta?eda, Raúl,Ordonez, Carlos,Li, Zhong'An,Chi, San-Hui,Jang, Sei-Hum,Parker, Timothy C.,Timofeeva, Tatiana V.,Perry, Joseph W.,Jen, Alex K.-Y.,Hagan, David J.,Van Stryland, Eric W.,Marder, Seth R.
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supporting information
p. 10112 - 10115
(2016/08/31)
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