- Method for continuously producing O-tert-butyl-L-threonine tert-butyl ester
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The invention relates to a method for continuously producing O-tert-butyl-L-threonine tert-butyl ester. By selecting ZSM-5 supported silicotungstic acid as a catalyst and adopting a mode of connectingtwo tubular reactions in series, the invention provides the method for continuously producing O-tert-butyl-L-threonine tert-butyl ester, wherein the method is suitable for industrial production, theyield of the preparation method is greater than 80%, the purity is greater than 99%, and the preparation method is simple in process and suitable for industrial production requirements.
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Paragraph 0028; 0030-0032; 0034-0036; 0038-0040; 0042
(2020/03/06)
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- Preparation method of O-tert-butyl-L-threonine tert-butyl ester
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The invention discloses a preparation method of O-tert-butyl-L-threonine tert-butyl ester. The method comprises the following steps of adding L-threonine and hydrophilic organic solvents into a reaction kettle; dripping an organic acid catalyst at -20 DEG C to 20 DEG C, wherein the hydrophilic organic solvents are solvents containing C3-C8 ester; after the reaction is completed, adding isobutylene at -50 DEG C to 0 DEG C; then, continuously performing reaction for 12 to 144 hours at the temperature; then, ending the reaction; adding water and ammonium hydroxide at -5 DEG C to 5 DEG C until the pH is 7.5 to 8.0; separating out an organic phase; adding ethyl acetate into a water phase for extraction; merging an organic phase; washing the organic phase by water; performing drying and reduced pressure concentration on the organic phase to obtain O-tert-butyl-L-threonine tert-butyl ester crude products; purifying the crude products by finished acetic acid salts. The preparation method provided by the invention has the advantages that the process is simple; safety, environment protection, high yield and low cost are realized; the mass production requirements are met.
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Paragraph 0028; 0029; 0030; 0031; 0032; 0033; 0034-0047
(2017/08/27)
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- An efficient synthesis of tert-butyl ethers/esters of alcohols/amino acids using methyl tert-butyl ether
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A facile synthesis of a wide variety of tert-butyl ethers and tert-butyl ester derivatives under mild conditions is described. Alcohols etherified with tert-butyl methyl ether as tert-butyl source and solvent, in the presence of sulfuric acid. Many amino acid tert-butyl esters have been synthesized by this procedure. The reaction is simple, inexpensive, easily scaled up, and proceeds without observable racemization. A green method was developed for the deprotection of this group using Amberlite resin IR 120-H as catalyst.
- Mallesha,Prahlada Rao,Suhas,Channe Gowda
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experimental part
p. 641 - 645
(2012/02/15)
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- METHOD FOR THE MANUFACTURE OF L-THREONINE-O-(1,1-DIMETHYLETHYL)-1,1-DIMETHYLETHYL ESTER
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The present invention relates to a new and efficient process for the manufacture of L-Threonine-O-(1,1-dimethylethyl) ester; [H-Thr-(tBu)-O-tBu] of Formula (I). The compound of Formula (I) is a key product for the manufacture of human insulin from porcine or bovine insulin.
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Page/Page column 5
(2008/06/13)
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- Synthesis and biological activities of TAN-1511 analogues
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TAN-1511 analogues were synthesized and their effects on the proliferation of bone marrow cells were examined. To exert potent activity the following conditions are necessary: the configuration of the 2-amino-6,7-dihydroxy-4-thiaheptanoic acid moiety must be (2R,6R), long chain acyl groups (C14 to C18) must be bound to both hydroxyl groups, the amino group must be free or acylated with the long chain fatty acid (ca. C14) and the peptide moiety must have glutamic acid as a component. Among the synthesized compounds, trisodium (2R,6R)-2-amino-6,7-bis (hexadecanoyloxy)-4-thiaheptanoyl glycyl glutamyl glutamate, which has improved solubility, was effective in experimental leukocytopenia in mice.
- Hida,Hayashi,Yukishige,Tanida,Kawamura,Harada
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p. 589 - 603
(2007/10/02)
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