- Treatment of mitochondrial diseases
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The invention relates the method of treatment or amelioration of mitochondrial disorders such as Alzheimer's disease, Parkinson's disease, Friedreich's ataxia (FRDA), cerebellar ataxias, Leber's hereditary optic neuropathy (LHON), mitochondrial myopathy,
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- Orientation-Selected 95 GHz High-Field ENDOR Spectroscopy of Randomly Oriented Plastoquinone Anion Radicals
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Recent improvements of a 3 mm high-field/high-frequency CW EPR/ENDOR spectrometer are presented, making it possible for ENDOR measurements to be performed with N
- Rohrer, M.,Plato, M.,Macmillan, F.,Grishin, Y.,Lubitz, W.,Moebius, K.
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- Allylation of Quinones with Allyltin Reagents
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Lewis acid (BF3) catalyzed allylation of quinones with allyl- (2a), 2-methyl-2-propenyl- (2b), trans-2-butenyl- (2c,d), 3-methyl-2-butenyl- (2e,f), and trans-cinnamyltrialkyltin (2g) gives the corresponding allylhydroquinones with high regioselectivity.Vitamin K2(5) (7) and coenzyme Q1 (9) were prepared in yields of 78 and 75percent, respectively.These reactions appear to proceed through allylquinol intermediates which undergo rearrangement under the influence of BF3.The success of this synthesis of vitamin K2(5) and coenzyme Q1 depends on the fact that the reaction of 3-methyl-2-butenyltin with quinones occurs at the α carbon of the allylic system.
- Naruta, Yoshinori
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p. 3774 - 3783
(2007/10/02)
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