Base-catalyzed carbon-carbon bond formation reactions of ω-hydroxylactams
Active methylene compounds such as methyl ketones, 1,3-dicarbonyl systems and nitromethane condense under the influence of base with ω-hydroxylactams, thereby forming α-alkylated nitrogen heterocycles.The ease of alkylation is detemined by the position of a tautomeric equilibrium between ω-hydroxylactam and the open-chain amide-aldehyde, which is dependent upon the type of N-substituent and upon the lactam ring size.Some applications for the products obtained are indicated.
Speckamp, W. N.,Boer, J. J. J. de
p. 410 - 414
(2007/10/02)
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