cas 58880-37-8, 1-(4-CHLOROPHENYL)-1-CYCLOHEXANECARBOXYLIC ACID | Articles data ｜lookchem

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58880-37-8

Articles about 58880-37-8Total 1 be found

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Discovery of N-methyl-1-(1-phenylcyclohexyl)methanamine, a novel triple serotonin, norepinephrine, and dopamine reuptake inhibitor
The current work discloses a novel cyclohexylarylamine chemotype with potent inhibition of the serotonin, norepinephrine, and dopamine transporters and potential for treatment of major depressive disorder. Optimized compounds 1 (SERT, NET, DAT, IC50 = 169, 85, 21 nM) and 42 (SERT, NET, DAT IC50 = 34, 295, 90 nM) were highly brain penetrant, active in vivo in the mouse tail suspension test at 30 mpk po and were not general motor stimulants.
Shao, Liming,Hewitt, Michael C.,Wang, Fengjiang,Malcolm, Scott C.,Ma, Jianguo,Campbell, John E.,Campbell, Una C.,Engel, Sharon R.,Spicer, Nancy A.,Hardy, Larry W.,Schreiber, Rudy,Spear, Kerry L.,Varney, Mark A.
p. 1438 - 1441
(2011/04/16)

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Chemical Properties

Appearance/Colour :Light grey powder and granules
Melting Point: 150-156 °C
Boiling Point: 378.9 °C at 760 mmHg
Flash Point:183 °C
Density: 1.235 g/cm³
Storage Temp.:Sealed in dry,Room Temperature
Vapor Pressure: 2.04E-06mmHg at 25°C
Refractive Index: 1.5380 (estimate)
PKA: 4.34±0.20(Predicted)
BRN: 3297868
PSA: 37.30000
LogP: 3.62650

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