Divergent Synthesis of Bicyclo[3.2.1]octenes and Cyclohexenes via Catalytic Annulations of Nazarov Reagent and Vinyl 1,2-Diketones
Bicyclo[3.2.1]octanes and related structures are unique units that widely exist in natural products, but the rapid and stereoselective construction of this skeleton is a challenging issue. We report the stereodivergent synthesis of bicyclo[3.2.1]octenes u
Chemoenzymatic synthesis of chiral unsymmetrical benzoin esters
A chemoenzymatic Dynamic Kinetic Resolution (DKR) of unsymmetrical benzoins (Ar1≠Ar2) has been carried out, by using Pseudomonas stutzeri lipase stereorecognition pattern. After studying this lipase behaviour, a high preference towards acylation of those benzoins containing substituents in the phenyl ring rather than in the benzoyl moiety was observed. This fact allowed the development of the DKR process of this kind of substrates, avoiding the accumulation of secondary products derived from the in situ racemization mediated by Shvo's catalyst action, and allowing the synthesis of enantiopure unsymmetrical benzoins acetates (not previously described) in very good yields (60-95%) and excellent enantiomeric excess values (always >99%).
Hoyos, Pilar,Pace, Vittorio,Sinisterra, José V.,Alcántara, Andrés R.
experimental part
p. 7321 - 7329
(2011/10/09)
1,3-Dithiane derivatives as radioprotective agents
Compounds derived from 1,3 dithiane have been prepared and evaluated as potential antiradiation agents in mice. They are generally less toxic than their dithiolane homologs and have markedly lower radioprotective activity.
Fernandez,Robbe,Chapat,et al.
p. 461 - 464
(2007/10/02)
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