- A urea compound, preparation method and its use
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Provided are a urea compound having a structure as represented by general formula I, preparation method thereof, pharmaceutical composition containing the compound, and uses thereof in the preparation of drugs for treating inflammatory response, immune hyperactivity and organ transplantation rejection, wherein R1-R7, X, Y and n in the general formula are as defined in the specification and the claims.
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Paragraph 0162; 0163; 0164; 0165
(2016/10/08)
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- Process for preparing cyclo-1,3,2-oxazaphosphoryl derivatives
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A novel process for preparing cyclo-1,3,2-oxazaphosphoryl derivatives represented by the formula (II), STR1 wherein R2 and R3 are respectively a lower alkyl group which may have halogen atom(s) or lower alkane-sulfonyloxy group(s) as substituted group(s) and n is an integer of 2 to 6, by acid cleaving the R1 --N bond of the compound represented by the formula (I), STR2 wherein R1 is an α-arylalkyl group, by using a strong acid, the compound represented by the formula (II) being effective as an anticancer agent.
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