Synthesis and biological activity of new functionalized epothilones for prodrug design and tumor targeting
Epothilones are potent antiproliferative agents, which have served as successful lead structures for anticancer drug discovery. However, their therapeutic efficacy would benefit greatly from an increase in their selectivity for tumor cells, which may be a
BENZAMIDE DERIVATIVES AS INHIBITORS OF HISTONE DEACETYLASE
The invention relates to the inhibition of histone deacetylase. The invention provides compounds which are derivatives of benzamide and suitable in methods for inhibiting histone deacetylase enzymatic activity. The invention also provides compositions and methods for treating cell proliferative diseases and conditions .
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Page/Page column 112-113
(2008/06/13)
INHIBITORS OF HISTONE DEACETYLASE
The invention relates to the inhibition of histone deacetylase. The invention provides compounds and methods for inhibiting histone deacetylase enzymatic activity. The invention also provides compositions and methods for treating cell proliferative diseases and conditions.
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Page/Page column 252
(2010/02/11)
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