59410-24-1

The invention belongs to the technical field of compound preparation, and discloses a method of using a solid acid catalyst to synthesize an amide-type cooling agent. According to the method, 2,2-diisopropyl propane nitrile, C1-C6 lower aliphatic alcohols, and water are taken as the raw materials; and under the action of a solid acid catalyst, thermostatic alcoholysis circular reactions are carried out in a fixed bed reactor. Solid acids are used to replace liquid acids, the problem that a large amount of low concentration acidic wastewater is generated in conventional cooling agent production is solved, the discharge of waste solid, waste gas, and wastewater is reduced, at the same time, the corrosion on production equipment is largely reduced; the method is green and environmentally friendly; a fixed bed reactor is adopted, an outer circulation type reaction technology is used, the alcoholysis process of converting cyano groups into N-alkyl amide is smoothly carried out, the lower aliphatic alcohols can be circularly used after being separated by a gas-liquid separator; the raw material waste is reduced, and continuous production is realized.