A new synthesis of amides and γ-lactones based on the conjugate addition of lithium enolate of amides to 1-chlorovinyl p-tolyl sulfoxides
Reaction of 1-chlorovinyl p-tolyl sulfoxides, which were synthesized from chloromethyl p-tolyl sulfoxide and ketones or aldehydes, with lithium enolate of N,N-dimethylacetamide gave the adducts in good to quantitative yields. The adducts were converted to
Satoh, Tsuyoshi,Kamide, Yuhki,Sugiyama, Shimpei
p. 11805 - 11812
(2007/10/03)
Conjugate addition of lithium ester enolates to 1-chlorovinyl p-tolyl sulfoxides: A novel synthesis of functionalized esters and lactones having a tertiary or a quaternary carbon at the β-position
Addition of the lithium ester enolates to 1-chlorovinyl p-tolyl sulfoxides, which were synthesized from chloromethyl p-tolyl sulfoxide and ketones or aldehydes, gave esters having a tertiary or a quaternary carbon at the 3-position, and chlorine and sulfi